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Integrating all required tools, programs and databases into a single web-based workspace facilitates access to homology modelling from a computer with web connection without the need of downloading and installing large program packages and databases.<\/jats:p>\n               <jats:p>Results: SWISS-MODEL workspace is a web-based integrated service dedicated to protein structure homology modelling. It assists and guides the user in building protein homology models at different levels of complexity. A personal working environment is provided for each user where several modelling projects can be carried out in parallel. Protein sequence and structure databases necessary for modelling are accessible from the workspace and are updated in regular intervals. Tools for template selection, model building and structure quality evaluation can be invoked from within the workspace. Workflow and usage of the workspace are illustrated by modelling human Cyclin A1 and human Transmembrane Protease 3.<\/jats:p>\n               <jats:p>Availability: The SWISS-MODEL workspace can be accessed freely at<\/jats:p>\n               <jats:p>Contact: \u00a0Torsten.Schwede@unibas.ch<\/jats:p>\n               <jats:p>Supplementary information: Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bti770","type":"journal-article","created":{"date-parts":[[2005,11,15]],"date-time":"2005-11-15T01:12:33Z","timestamp":1132017153000},"page":"195-201","source":"Crossref","is-referenced-by-count":6012,"title":["The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling"],"prefix":"10.1093","volume":"22","author":[{"given":"Konstantin","family":"Arnold","sequence":"first","affiliation":[{"name":"Biozentrum Basel, University of Basel 1 \u00a0 1 \u00a0 \u00a0 Switzerland"},{"name":"Swiss Institute of Bioinformatics 2 \u00a0 2 \u00a0 \u00a0 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Bordoli","sequence":"additional","affiliation":[{"name":"Biozentrum Basel, University of Basel 1 \u00a0 1 \u00a0 \u00a0 Switzerland"},{"name":"Swiss Institute of Bioinformatics 2 \u00a0 2 \u00a0 \u00a0 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Kopp","sequence":"additional","affiliation":[{"name":"Biozentrum Basel, University of Basel 1 \u00a0 1 \u00a0 \u00a0 Switzerland"},{"name":"Swiss Institute of Bioinformatics 2 \u00a0 2 \u00a0 \u00a0 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Schwede","sequence":"additional","affiliation":[{"name":"Biozentrum Basel, University of Basel 1 \u00a0 1 \u00a0 \u00a0 Switzerland"},{"name":"Swiss Institute of Bioinformatics 2 \u00a0 2 \u00a0 \u00a0 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,11,13]]},"reference":[{"key":"2023012408301582000_b1","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"2023012408301582000_b2","doi-asserted-by":"crossref","first-page":"D226","DOI":"10.1093\/nar\/gkh039","article-title":"SCOP database in 2004: refinements integrate structure and sequence family data","volume":"32","author":"Andreeva","year":"2004","journal-title":"Nucleic Acids Res."},{"issue":"Database Issue","key":"2023012408301582000_b3","doi-asserted-by":"crossref","first-page":"D154","DOI":"10.1093\/nar\/gki070","article-title":"The Universal Protein Resource (UniProt)","volume":"33","author":"Bairoch","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"2023012408301582000_b4","doi-asserted-by":"crossref","first-page":"D138","DOI":"10.1093\/nar\/gkh121","article-title":"The Pfam protein families database","volume":"32","author":"Bateman","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"2023012408301582000_b5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/prot.1168","article-title":"Enhancement of protein modeling by human intervention in applying the automatic programs 3D-JIGSAW and 3D-PSSM","author":"Bates","year":"2001","journal-title":"Proteins"},{"key":"2023012408301582000_b6","doi-asserted-by":"crossref","first-page":"13059","DOI":"10.1021\/bi00040a017","article-title":"Disulfide bridges of a cysteine-rich repeat of the LDL receptor ligand-binding domain","volume":"34","author":"Bieri","year":"1995","journal-title":"Biochemistry"},{"key":"2023012408301582000_b7","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/357543a0","article-title":"Proteins. 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