{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T20:26:14Z","timestamp":1684527974939},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Grouping of gene expression patterns across biological experiments, treatments and time-series data is performed in q-intervals of measurements using phase-shifted analysis of gene expression (PAGE); a Java-based tool to find clusters of genes that share trends of expression profiles within the dataset. The patterns and genes within q-Clusters are visualized in trend plots and compared to determine biological relevance from the gene annotations.<\/jats:p>\n               <jats:p>Availability: PAGE is available at<\/jats:p>\n               <jats:p>Contact: \u00a0bushel@niehs.nih.gov<\/jats:p>\n               <jats:p>Supplementary information: The Supplementary data are available at<\/jats:p>","DOI":"10.1093\/bioinformatics\/bti778","type":"journal-article","created":{"date-parts":[[2005,12,2]],"date-time":"2005-12-02T01:14:08Z","timestamp":1133486048000},"page":"367-368","source":"Crossref","is-referenced-by-count":4,"title":["PAGE: phase-shifted analysis of gene expression"],"prefix":"10.1093","volume":"22","author":[{"given":"Elo","family":"Leung","sequence":"first","affiliation":[{"name":"Bioinformatics and Computational Biology, School of Computational Sciences, George Mason University 1 \u00a0 1 \u00a0 \u00a0 Manassas, VA 20110, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre R.","family":"Bushel","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, National Center for Toxicogenomics, Microarray Group, Research Triangle Park 2 \u00a0 2 \u00a0 \u00a0 NC 27709, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,12,1]]},"reference":[{"key":"2023012408335898700_b1","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: Database for Annotation, Visualization, and Integrated Discovery","volume":"4","author":"Dennis","year":"2003","journal-title":"Genome Biol."},{"key":"2023012408335898700_b2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.mrfmmm.2003.12.021","article-title":"Integration of clinical and gene expression endpoints to explore furan-mediated hepatotoxicity","volume":"549","author":"Hamadeh","year":"2004","journal-title":"Mutat. Res."},{"key":"2023012408335898700_b3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/toxsci\/kfh145","article-title":"Gene expression profiling of rat livers reveals indicators of potential adverse effects","volume":"80","author":"Heinloth","year":"2004","journal-title":"Toxicol. Sci."},{"key":"2023012408335898700_b4","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/ng1522","article-title":"Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease","volume":"37","author":"Hubner","year":"2005","journal-title":"Nat. Genet."},{"key":"2023012408335898700_b5","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/bioinformatics\/bti026","article-title":"Identifying time-lagged gene clusters using gene expression data","volume":"21","author":"Ji","year":"2005","journal-title":"Bioinformatics"},{"key":"2023012408335898700_b6","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1089\/10665270360688165","article-title":"Phase-independent rhythmic analysis of genome-wide expression patterns","volume":"10","author":"Langmead","year":"2003","journal-title":"J. Comput. Biol."},{"key":"2023012408335898700_b7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1006\/taap.2001.9243","article-title":"Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles","volume":"175","author":"Waring","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/22\/3\/367\/48839174\/bioinformatics_22_3_367.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/22\/3\/367\/48839174\/bioinformatics_22_3_367.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T08:37:35Z","timestamp":1674549455000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/22\/3\/367\/220060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12,1]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bti778","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2006,2,1]]},"published":{"date-parts":[[2005,12,1]]}}}