{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T01:14:48Z","timestamp":1770340488985,"version":"3.49.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Investigators conducting studies of the molecular genetics of complex traits in humans often need rationally to select a set of single nucleotide polymorphisms (SNPs) from the hundreds or thousands available for a candidate gene. Accomplishing this requires integration of genomic data from distributed databases and is both time-consuming and error-prone. We developed the TAMAL (Technology And Money Are Limiting) web site to help identify promising SNPs for further investigation. For a given list of genes, TAMAL identifies SNPs that meet user-specified criteria (e.g. haplotype tagging SNPs or SNP predicted to lead to amino acid changes) from current versions of online resources (i.e. HapMap, Perlegen, Affymetrix, dbSNP and the UCSC genome browser).<\/jats:p>\n               <jats:p>Availability: TAMAL is a platform independent web-based application available free of charge at<\/jats:p>\n               <jats:p>Contact: pfsulliv@med.unc.edu<\/jats:p>\n               <jats:p>Supplementary information:<\/jats:p>","DOI":"10.1093\/bioinformatics\/btk025","type":"journal-article","created":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T03:13:59Z","timestamp":1137554039000},"page":"626-627","source":"Crossref","is-referenced-by-count":58,"title":["TAMAL: an integrated approach to choosing SNPs for genetic studies of human complex traits"],"prefix":"10.1093","volume":"22","author":[{"given":"Bradley M.","family":"Hemminger","sequence":"first","affiliation":[{"name":"School of Information and Library Science, University of North Carolina at Chapel Hill 1 \u00a0 1 \u00a0 \u00a0 Chapel Hill NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Billy","family":"Saelim","sequence":"additional","affiliation":[{"name":"School of Information and Library Science, University of North Carolina at Chapel Hill 1 \u00a0 1 \u00a0 \u00a0 Chapel Hill NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick F.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of North Carolina at Chapel Hill 2 \u00a0 2 \u00a0 \u00a0 Chapel Hill NC, USA"},{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet 3 \u00a0 3 \u00a0 \u00a0 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,1,17]]},"reference":[{"key":"2023012408533788200_b1","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nature04226","article-title":"A haplotype map of the human genome","volume":"437","author":"Altshuler","year":"2005","journal-title":"Nature"},{"key":"2023012408533788200_b2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2004","journal-title":"Bioinformatics"},{"key":"2023012408533788200_b3","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1101\/gr.1933104","article-title":"Aligning multiple genomic sequences with the threaded blockset aligner","volume":"14","author":"Blanchette","year":"2004","journal-title":"Genome Res."},{"key":"2023012408533788200_b4","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1126\/science.1069424","article-title":"The structure of haplotype blocks in the human genome","volume":"296","author":"Gabriel","year":"2002","journal-title":"Science"},{"key":"2023012408533788200_b5","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1093\/bioinformatics\/bti442","article-title":"LS-SNP: large-scale annotation of coding non-synonymous SNPs based on multiple information sources","volume":"21","author":"Karchin","year":"2005","journal-title":"Bioinformatics"},{"key":"2023012408533788200_b6","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","article-title":"Initial sequencing and analysis of the human genome","volume":"409","author":"Lander","year":"2001","journal-title":"Nature"},{"key":"2023012408533788200_b7","first-page":"277","article-title":"Combining phylogenetic and hidden Markov models in biosequence analysis","author":"Siepel","year":"2003"},{"key":"2023012408533788200_b8","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nature02168","article-title":"The International HapMap Project","volume":"426","author":"The International HapMap Consortium","year":"2003","journal-title":"Nature"},{"key":"2023012408533788200_b9","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1101\/gr.794803","article-title":"Identification and functional analysis of human transcriptional promoters","volume":"13","author":"Trinklein","year":"2003","journal-title":"Genome Res."},{"key":"2023012408533788200_b10","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1086\/378099","article-title":"Assessing the performance of the haplotype block model of linkage disequilibrium","volume":"73","author":"Wall","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"2023012408533788200_b11","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nrg1123","article-title":"Haplotype blocks and linkage disequilibrium in the human genome","volume":"4","author":"Wall","year":"2003","journal-title":"Nat. Rev. Genet."}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/22\/5\/626\/48839785\/bioinformatics_22_5_626.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/22\/5\/626\/48839785\/bioinformatics_22_5_626.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T09:32:41Z","timestamp":1674552761000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/22\/5\/626\/205877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,17]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btk025","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2006,3,1]]},"published":{"date-parts":[[2006,1,17]]}}}