{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:58:35Z","timestamp":1770479915042,"version":"3.49.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Genomic sequences are highly redundant and contain many types of repetitive DNA. Fuzzy tandem repeats (FTRs) are of particular interest. They are found in regulatory regions of eukaryotic genes and are reported to interact with transcription factors. However, accurate assessment of FTR occurrences in different genome segments requires specific algorithm for efficient FTR identification and classification.<\/jats:p>\n               <jats:p>Results: We have obtained formulas for P-values of FTR occurrence and developed an FTR identification algorithm implemented in TandemSWAN software. Using TandemSWAN we compared the structure and the occurrence of FTRs with short period length (up to 24 bp) in coding and non-coding regions including UTRs, heterochromatic, intergenic and enhancer sequences of Drosophila melanogaster and Drosophila pseudoobscura. Tandems with period three and its multiples were found in coding segments, whereas FTRs with periods multiple of six are overrepresented in all non-coding segment. Periods equal to 5\u20137 and 11\u201314 were characteristic of the enhancer regions and other non-coding regions close to genes.<\/jats:p>\n               <jats:p>Availability: TandemSWAN web page, stand-alone version and documentation can be found at<\/jats:p>\n               <jats:p>Contacts: valeyo@imb.ac.ru<\/jats:p>\n               <jats:p>Supplementary information: Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btk032","type":"journal-article","created":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T01:18:22Z","timestamp":1136942302000},"page":"676-684","source":"Crossref","is-referenced-by-count":75,"title":["Short fuzzy tandem repeats in genomic sequences, identification, and possible role in regulation of gene expression"],"prefix":"10.1093","volume":"22","author":[{"given":"Valentina","family":"Boeva","sequence":"first","affiliation":[{"name":"Department of Bioengineering and Bioinformatics, Moscow State University 1 \u00a0 1 \u00a0 \u00a0 Moscow, Russia"}]},{"given":"Mireille","family":"Regnier","sequence":"additional","affiliation":[{"name":"INRIA Rocquencourt 2 \u00a0 2 \u00a0 \u00a0 France"}]},{"given":"Dmitri","family":"Papatsenko","sequence":"additional","affiliation":[{"name":"University of California 3 \u00a0 3 \u00a0 \u00a0 Berkeley, USA"}]},{"given":"Vsevolod","family":"Makeev","sequence":"additional","affiliation":[{"name":"State Research Center GosNIIGenetika 4 \u00a0 4 \u00a0 \u00a0 Moscow, Russia"},{"name":"Engelhardt Institute of Molecular Biology, Russian Academy of Sciences 5 \u00a0 5 \u00a0 \u00a0 Moscow, Russia"}]}],"member":"286","published-online":{"date-parts":[[2006,1,10]]},"reference":[{"key":"2023012408535192500_b1","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1128\/MCB.16.6.2977","article-title":"Direct repeats bind the EcR\/USP receptor and mediate ecdysteroid responses in Drosophila melanogaster","volume":"16","author":"Antoniewski","year":"1996","journal-title":"Mol. 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