{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T22:00:23Z","timestamp":1775858423936,"version":"3.50.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Phage display is a widespread technique used to obtain peptide mimotopes selected by binding to a given monoclonal antibody in a similar way as the native epitope. However, the localization of the interaction site mimicked by the mimotopes on the surface of the antigen is not always a straightforward task. MIMOP is a computational tool developed with the aim of helping experimentalists to analyze a set of mimotope sequences and guide them in the identification of the mimicked region.<\/jats:p>\n               <jats:p>Results: To predict potential epitopic regions, MIMOP integrates two different approaches combining two- and three-dimensional analyses: MimAlign starts from degenerated alignment analyses, and MimCons is based on consensus identification. The relevance and usefulness of the tool are illustrated by four use cases corresponding to real-life situations.<\/jats:p>\n               <jats:p>Availability: upon request.<\/jats:p>\n               <jats:p>Contact: \u00a0franck.molina@cpbs.univ-montp1.fr<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl012","type":"journal-article","created":{"date-parts":[[2006,1,25]],"date-time":"2006-01-25T02:48:15Z","timestamp":1138157295000},"page":"1088-1095","source":"Crossref","is-referenced-by-count":89,"title":["Discontinuous epitope prediction based on mimotope analysis"],"prefix":"10.1093","volume":"22","author":[{"given":"Violaine","family":"Moreau","sequence":"first","affiliation":[{"name":"CNRS UMR 5160, Centre de Pharmacologie et Biotechnologie pour la Sant\u00e9 \u00a0 Facult\u00e9 de Pharmacie, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France"}]},{"given":"Claude","family":"Granier","sequence":"additional","affiliation":[{"name":"CNRS UMR 5160, Centre de Pharmacologie et Biotechnologie pour la Sant\u00e9 \u00a0 Facult\u00e9 de Pharmacie, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France"}]},{"given":"Sylvie","family":"Villard","sequence":"additional","affiliation":[{"name":"CNRS UMR 5160, Centre de Pharmacologie et Biotechnologie pour la Sant\u00e9 \u00a0 Facult\u00e9 de Pharmacie, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France"}]},{"given":"Daniel","family":"Laune","sequence":"additional","affiliation":[{"name":"CNRS UMR 5160, Centre de Pharmacologie et Biotechnologie pour la Sant\u00e9 \u00a0 Facult\u00e9 de Pharmacie, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France"}]},{"given":"Franck","family":"Molina","sequence":"additional","affiliation":[{"name":"CNRS UMR 5160, Centre de Pharmacologie et Biotechnologie pour la Sant\u00e9 \u00a0 Facult\u00e9 de Pharmacie, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France"}]}],"member":"286","published-online":{"date-parts":[[2006,1,24]]},"reference":[{"key":"2023012409155418200_b1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.toxicon.2003.09.006","article-title":"Production of monoclonal antibodies capable of neutralizing dermonecrotic activity of Loxosceles intermedia spider venom and their use in a specific immunometric assay","volume":"42","author":"Alvarenga","year":"2003","journal-title":"Toxicon"},{"key":"2023012409155418200_b2","doi-asserted-by":"crossref","first-page":"16974","DOI":"10.1074\/jbc.270.28.16974","article-title":"Topological mapping of neutrophil cytochrome b epitopes with phage-display libraries","volume":"270","author":"Burritt","year":"1995","journal-title":"J. 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