{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T03:05:28Z","timestamp":1780110328388,"version":"3.54.0"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Short interfering RNAs (siRNAs) have been gaining popularity as the gene knock-down tool of choice by many researchers because of the clean nature of their workings as well as the technical simplicity and cost efficiency in their applications. We have constructed siRecords, a database of siRNAs experimentally tested by researchers with consistent efficacy ratings. This database will help siRNA researchers develop more reliable siRNA design rules; in the mean time, siRecords will benefit experimental researchers directly by providing them with information about the siRNAs that have been experimentally tested against the genes of their interest. Currently, more than 4100 carefully annotated siRNA sequences obtained from more than 1200 published siRNA studies are hosted in siRecords. This database will continue to expand as more experimentally tested siRNAs are published.<\/jats:p>\n               <jats:p>Availability: The siRecords database can be accessed at<\/jats:p>\n               <jats:p>Contact: \u00a0toli@biocompute.umn.edu<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl026","type":"journal-article","created":{"date-parts":[[2006,1,29]],"date-time":"2006-01-29T01:23:19Z","timestamp":1138497799000},"page":"1027-1028","source":"Crossref","is-referenced-by-count":39,"title":["siRecords: an extensive database of mammalian siRNAs with efficacy ratings"],"prefix":"10.1093","volume":"22","author":[{"given":"Yongliang","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Neuroscience, University of Minnesota \u00a0 Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuming","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Minnesota \u00a0 Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Minnesota \u00a0 Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Minnesota \u00a0 Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Minnesota \u00a0 Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yejun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Minnesota \u00a0 Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongbin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Minnesota \u00a0 Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,1,28]]},"reference":[{"key":"2023012409195243800_b1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.bbrc.2004.04.181","article-title":"Improved and automated prediction of effective siRNA","volume":"319","author":"Chalk","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023012409195243800_b2","doi-asserted-by":"crossref","first-page":"D131","DOI":"10.1093\/nar\/gki136","article-title":"siRNAdb: a database of siRNA sequences","volume":"33","author":"Chalk","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"2023012409195243800_b3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cmpb.2003.09.002","article-title":"OptiRNAi, an RNAi design tool","volume":"75","author":"Cui","year":"2004","journal-title":"Comput. Methods Programs Biomed."},{"key":"2023012409195243800_b4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1046-2023(02)00023-3","article-title":"Analysis of gene function in somatic mammalian cells using small interfering RNAs","volume":"26","author":"Elbashir","year":"2002","journal-title":"Methods"},{"key":"2023012409195243800_b5","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1093\/nar\/30.8.1757","article-title":"Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor","volume":"30","author":"Holen","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"2023012409195243800_b6","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/nar\/gkh238","article-title":"A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens","volume":"32","author":"Hsieh","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"2023012409195243800_b7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0092-8674(03)00801-8","article-title":"Functional siRNAs and miRNAs exhibit strand bias [Erratum (2003) Cell, 115, 505.]","volume":"115","author":"Khvorova","year":"2003","journal-title":"Cell"},{"key":"2023012409195243800_b8","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nbt936","article-title":"Rational siRNA design for RNA interference","volume":"22","author":"Reynolds","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"2023012409195243800_b9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.bbrc.2004.06.116","article-title":"A comparison of siRNA efficacy predictors","volume":"321","author":"Saetrom","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023012409195243800_b10","doi-asserted-by":"crossref","first-page":"D108","DOI":"10.1093\/nar\/gki131","article-title":"HuSiDa\u2014the human siRNA database: an open-access database for published functional siRNA sequences and technical details of efficient transfer into recipient cells","volume":"33","author":"Truss","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"2023012409195243800_b11","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1093\/nar\/gkh247","article-title":"Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference","volume":"32","author":"Ui-Tei","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"2023012409195243800_b12","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/bioinformatics\/bth498","article-title":"Filtering of ineffective siRNAs and improved siRNA design tool","volume":"21","author":"Yiu","year":"2005","journal-title":"Bioinformatics"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/22\/8\/1027\/48839764\/bioinformatics_22_8_1027.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/22\/8\/1027\/48839764\/bioinformatics_22_8_1027.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T09:57:05Z","timestamp":1674554225000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/22\/8\/1027\/226973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,28]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,4,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btl026","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2006,4,15]]},"published":{"date-parts":[[2006,1,28]]}}}