{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:21:31Z","timestamp":1758475291820},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Conserved domains represent essential building blocks of most known proteins. Owing to their role as modular components carrying out specific functions they form a network based both on functional relations and direct physical interactions. We have previously shown that domain interaction networks provide substantially novel information with respect to networks built on full-length protein chains. In this work we present a comprehensive web resource for exploring the Domain Interaction MAp (DIMA), interactively. The tool aims at integration of multiple data sources and prediction techniques, two of which have been implemented so far: domain phylogenetic profiling and experimentally demonstrated domain contacts from known three-dimensional structures. A powerful yet simple user interface enables the user to compute, visualize, navigate and download domain networks based on specific search criteria.<\/jats:p>\n               <jats:p>Availability: \u00a0<\/jats:p>\n               <jats:p>Contact: \u00a0p.pagel@gsf.de<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl050","type":"journal-article","created":{"date-parts":[[2006,2,16]],"date-time":"2006-02-16T01:13:15Z","timestamp":1140052395000},"page":"997-998","source":"Crossref","is-referenced-by-count":14,"title":["The DIMA web resource\u2014exploring the protein domain network"],"prefix":"10.1093","volume":"22","author":[{"given":"Philipp","family":"Pagel","sequence":"first","affiliation":[{"name":"Department of Genome Oriented Bioinformatics, Technical University of Munich 1 \u00a0 1 \u00a0 \u00a0 Wissenschaftszentrum Weihenstephan, 85350 Freising, Germany"},{"name":"Institute for Bioinformatics\/MIPS, GSF, Research Center for Environment and Health, Ingolst\u00e4dter Landstrasse 2 \u00a0 2 \u00a0 \u00a0 1, 85764 Neuherberg, Germany"}]},{"given":"Matthias","family":"Oesterheld","sequence":"additional","affiliation":[{"name":"Institute for Bioinformatics\/MIPS, GSF, Research Center for Environment and Health, Ingolst\u00e4dter Landstrasse 2 \u00a0 2 \u00a0 \u00a0 1, 85764 Neuherberg, Germany"}]},{"given":"Volker","family":"St\u00fcmpflen","sequence":"additional","affiliation":[{"name":"Institute for Bioinformatics\/MIPS, GSF, Research Center for Environment and Health, Ingolst\u00e4dter Landstrasse 2 \u00a0 2 \u00a0 \u00a0 1, 85764 Neuherberg, Germany"}]},{"given":"Dmitrij","family":"Frishman","sequence":"additional","affiliation":[{"name":"Department of Genome Oriented Bioinformatics, Technical University of Munich 1 \u00a0 1 \u00a0 \u00a0 Wissenschaftszentrum Weihenstephan, 85350 Freising, Germany"},{"name":"Institute for Bioinformatics\/MIPS, GSF, Research Center for Environment and Health, Ingolst\u00e4dter Landstrasse 2 \u00a0 2 \u00a0 \u00a0 1, 85764 Neuherberg, Germany"}]}],"member":"286","published-online":{"date-parts":[[2006,2,15]]},"reference":[{"key":"2023012409211570400_b1","doi-asserted-by":"crossref","first-page":"D138","DOI":"10.1093\/nar\/gkh121","article-title":"The Pfam protein families database","volume":"32","author":"Bateman","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"2023012409211570400_b2","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511790492","volume-title":"Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids","author":"Durbin","year":"1998"},{"key":"2023012409211570400_b3","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/bioinformatics\/bti011","article-title":"iPfam: visualization of protein-protein interactions in PDB at domain and amino acid resolutions","volume":"21","author":"Finn","year":"2005","journal-title":"Bioinformatics"},{"key":"2023012409211570400_b4","doi-asserted-by":"crossref","first-page":"D201","DOI":"10.1093\/nar\/gki106","article-title":"InterPro, progress and status in 2005","volume":"33","author":"Mulder","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"2023012409211570400_b5","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.jmb.2004.10.019","article-title":"A domain interaction map based on phylogenetic profiling","volume":"344","author":"Pagel","year":"2004","journal-title":"J. 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