{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:07:14Z","timestamp":1760954834974},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: The serial analysis of chromatin occupancy technique (SACO) promises to become a widely used method for the unbiased genome-wide experimental identification of loci bound by a transcription factor of interest. We describe the first web-based automatic tool, termed sequence tag analysis and reporting tool (START), for processing SACO data generated by experiments performed for the yeast, fruit fly, mouse, rat or human genomes. The program uses as input sequences of inserts from a SACO library from which it extracts all SACO tags, maps them to genomic locations and annotates them. START returns detailed information about these tags including the genes, the genomic elements and the miRNA precursors found in their vicinity, and makes use of the MAPPER database to identify putative transcription factor binding sites located close to the tags.<\/jats:p>\n               <jats:p>Availability: The program is available at<\/jats:p>\n               <jats:p>Contact: \u00a0vdmarinescu@chip.org<\/jats:p>\n               <jats:p>Supplementary information: Supplementary information is available at<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl062","type":"journal-article","created":{"date-parts":[[2006,2,25]],"date-time":"2006-02-25T01:14:23Z","timestamp":1140830063000},"page":"999-1001","source":"Crossref","is-referenced-by-count":5,"title":["START: an automated tool for serial analysis of chromatin occupancy data"],"prefix":"10.1093","volume":"22","author":[{"given":"Voichita D.","family":"Marinescu","sequence":"first","affiliation":[{"name":"Children's Hospital Informatics Program at the Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School 1 \u00a0 1 \u00a0 \u00a0 300 Longwood Avenue, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac S.","family":"Kohane","sequence":"additional","affiliation":[{"name":"Children's Hospital Informatics Program at the Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School 1 \u00a0 1 \u00a0 \u00a0 300 Longwood Avenue, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Children's Hospital Boston, Harvard Medical School 2 \u00a0 2 \u00a0 \u00a0 300 Longwood Avenue, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Harmin","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Children's Hospital Boston, Harvard Medical School 2 \u00a0 2 \u00a0 \u00a0 300 Longwood Avenue, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Children's Hospital Boston, Harvard Medical School 2 \u00a0 2 \u00a0 \u00a0 300 Longwood Avenue, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Riva","sequence":"additional","affiliation":[{"name":"Children's Hospital Informatics Program at the Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School 1 \u00a0 1 \u00a0 \u00a0 300 Longwood Avenue, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,2,24]]},"reference":[{"key":"2023012409205928000_b1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0092-8674(04)00127-8","article-title":"Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs","volume":"116","author":"Cawley","year":"2004","journal-title":"Cell"},{"key":"2023012409205928000_b2","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1073\/pnas.0407069102","article-title":"Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements","volume":"102","author":"Chen","year":"2005","journal-title":"Proc. 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