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We estimate evolutionary rates on multiple alignments of eukaryotic protein families in a maximum likelihood framework and spot sets of slow and fast evolving proteins.<\/jats:p>\n               <jats:p>Results: We find that the evolution of indispensable proteins is constrained by selection and that protein secretion is coupled to an increased evolutionary rate.<\/jats:p>\n               <jats:p>Contact: \u00a0luz@molgen.mpg.de<\/jats:p>\n               <jats:p>Supplementary information: \u00a0<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl073","type":"journal-article","created":{"date-parts":[[2006,3,2]],"date-time":"2006-03-02T01:24:53Z","timestamp":1141262693000},"page":"1166-1171","source":"Crossref","is-referenced-by-count":23,"title":["Family specific rates of protein evolution"],"prefix":"10.1093","volume":"22","author":[{"given":"Hannes","family":"Luz","sequence":"first","affiliation":[{"name":"Max Planck Institute for Molecular Genetics \u00a0 Ihnestrasse 73, 14195 Berlin, Germany"}]},{"given":"Martin","family":"Vingron","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Molecular Genetics \u00a0 Ihnestrasse 73, 14195 Berlin, Germany"}]}],"member":"286","published-online":{"date-parts":[[2006,3,1]]},"reference":[{"key":"2023012408205133900_b1","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1101\/gr.2195604","article-title":"The functional genomic distribution of protein divergence in two animal phyla: coevolution, genomic conflict, and constraint","volume":"14","author":"Castillo-Davis","year":"2004","journal-title":"Genome Res."},{"key":"2023012408205133900_b2","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1101\/gr.1659203","article-title":"Molecular correlates of genes exhibiting RNAi phenotypes in Caenorhabditis elegans","volume":"13","author":"Cutter","year":"2003","journal-title":"Genome Res."},{"key":"2023012408205133900_b3","doi-asserted-by":"crossref","first-page":"E55","DOI":"10.1371\/journal.pbio.0020055","article-title":"Preferential duplication of conserved proteins in eukaryotic genomes","volume":"2","author":"Davis","year":"2004","journal-title":"PLoS Biol"},{"key":"2023012408205133900_b4","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/bioinformatics\/14.9.755","article-title":"Profile hidden Markov models","volume":"14","author":"Eddy","year":"1998","journal-title":"Bioinformatics"},{"key":"2023012408205133900_b5","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4899-4541-9","article-title":"An Introduction to the Bootstrap","author":"Efron","year":"1993"},{"key":"2023012408205133900_b6","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/BF01734359","article-title":"Evolutionary trees from DNA sequences: a maximum likelihood approach","volume":"17","author":"Felsenstein","year":"1981","journal-title":"J. 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