{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:07:59Z","timestamp":1773274079669,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Besides classical clustering methods such as hierarchical clustering, in recent years biclustering has become a popular approach to analyze biological data sets, e.g. gene expression data. The Biclustering Analysis Toolbox (BicAT) is a software platform for clustering-based data analysis that integrates various biclustering and clustering techniques in terms of a common graphical user interface. Furthermore, BicAT provides different facilities for data preparation, inspection and postprocessing such as discretization, filtering of biclusters according to specific criteria or gene pair analysis for constructing gene interconnection graphs. The possibility to use different biclustering algorithms inside a single graphical tool allows the user to compare clustering results and choose the algorithm that best fits a specific biological scenario. The toolbox is described in the context of gene expression analysis, but is also applicable to other types of data, e.g. data from proteomics or synthetic lethal experiments.<\/jats:p>\n               <jats:p>Availability: The BicAT toolbox is freely available at and runs on all operating systems. The Java source code of the program and a developer's guide is provided on the website as well. Therefore, users may modify the program and add further algorithms or extensions.<\/jats:p>\n               <jats:p>Contact: \u00a0barkow@tik.ee.ethz.ch<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl099","type":"journal-article","created":{"date-parts":[[2006,3,22]],"date-time":"2006-03-22T02:33:29Z","timestamp":1142994809000},"page":"1282-1283","source":"Crossref","is-referenced-by-count":191,"title":["BicAT: a biclustering analysis toolbox"],"prefix":"10.1093","volume":"22","author":[{"given":"Simon","family":"Barkow","sequence":"first","affiliation":[{"name":"Reverse Engineering Group: Computer Engineering and Networks Laboratory, Swiss Federal Institute of Technology Zurich 1 \u00a0 1 \u00a0 \u00a0 ETH Zentrum, 8092 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Bleuler","sequence":"additional","affiliation":[{"name":"Reverse Engineering Group: Computer Engineering and Networks Laboratory, Swiss Federal Institute of Technology Zurich 1 \u00a0 1 \u00a0 \u00a0 ETH Zentrum, 8092 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amela","family":"Preli\u0107","sequence":"additional","affiliation":[{"name":"Reverse Engineering Group: Computer Engineering and Networks Laboratory, Swiss Federal Institute of Technology Zurich 1 \u00a0 1 \u00a0 \u00a0 ETH Zentrum, 8092 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Institute for Plant Sciences, Swiss Federal Institute of Technology Zurich 2 \u00a0 2 \u00a0 \u00a0 ETH Zentrum, 8092 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eckart","family":"Zitzler","sequence":"additional","affiliation":[{"name":"Reverse Engineering Group: Computer Engineering and Networks Laboratory, Swiss Federal Institute of Technology Zurich 1 \u00a0 1 \u00a0 \u00a0 ETH Zentrum, 8092 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,3,21]]},"reference":[{"key":"2023012408313116100_b1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1089\/10665270360688075","article-title":"Discovering local structure in gene expression data: the order-preserving submatrix problem","volume":"10","author":"Ben-Dor","year":"2003","journal-title":"J. Comput. Biol."},{"key":"2023012408313116100_b2","first-page":"93","article-title":"Biclustering of expression data","volume":"8","author":"Cheng","year":"2000","journal-title":"Proc. Int. Conf. Intell. Syst. Mol. Biol."},{"key":"2023012408313116100_b3","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/bioinformatics\/17.9.853","article-title":"BioLayout\u2014an automatic graph layout algorithm for similarity visualization","volume":"17","author":"Enright","year":"2001","journal-title":"Bioinformatics"},{"key":"2023012408313116100_b4","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/ng941","article-title":"Revealing modular organization in the yeast transcriptional network","volume":"31","author":"Ihmels","year":"2002","journal-title":"Nat. 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