{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:11:06Z","timestamp":1768320666028,"version":"3.49.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: We report a novel protein domain\u2014G8\u2014which contains five repeated \u03b2-strand pairs and is present in some disease-related proteins such as PKHD1, KIAA1199, TMEM2 as well as other uncharacterized proteins. Most G8-containing proteins are predicted to be membrane-integral or secreted. The G8 domain may be involved in extracellular ligand binding and catalysis. It has been reported that mis-sense mutations in the two G8 domains of human PKHD1 protein resulted in a less stable protein and are associated with autosomal-recessive polycystic kidney disease, indicating the importance of the domain structure. G8 is also present in the N-terminus of some non-syndromic hearing loss disease-related proteins such as KIAA1109 and TMEM2. Discovery of G8 domain will be important for the research of the structure\/function of related proteins and beneficial for the development of novel therapeutics.<\/jats:p>\n               <jats:p>Contact: \u00a0liangsp@hunnu.edu.cn<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl123","type":"journal-article","created":{"date-parts":[[2006,4,22]],"date-time":"2006-04-22T00:27:33Z","timestamp":1145665653000},"page":"2189-2191","source":"Crossref","is-referenced-by-count":52,"title":["G8: a novel domain associated with polycystic kidney disease and non-syndromic hearing loss"],"prefix":"10.1093","volume":"22","author":[{"given":"Quan-yuan","family":"He","sequence":"first","affiliation":[{"name":"Key Laboratory of Protein Chemistry and Developmental Biology of Education Committee, College of Life Sciences, Hunan Normal University 1 \u00a0 1 \u00a0 \u00a0 Changsha, People's Republic of China"}]},{"given":"Xiang-hua","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University 2 \u00a0 2 \u00a0 \u00a0 Handan Road 220, Shanghai 200433, People's Republic of China"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University 2 \u00a0 2 \u00a0 \u00a0 Handan Road 220, Shanghai 200433, People's Republic of China"}]},{"given":"David J.","family":"Studholme","sequence":"additional","affiliation":[{"name":"The Sainsbury Laboratory 3 \u00a0 3 \u00a0 \u00a0 Norwich NR4 7UH, UK"}]},{"given":"Xuan-wen","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Protein Chemistry and Developmental Biology of Education Committee, College of Life Sciences, Hunan Normal University 1 \u00a0 1 \u00a0 \u00a0 Changsha, People's Republic of China"}]},{"given":"Song-ping","family":"Liang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Protein Chemistry and Developmental Biology of Education Committee, College of Life Sciences, Hunan Normal University 1 \u00a0 1 \u00a0 \u00a0 Changsha, People's Republic of China"}]}],"member":"286","published-online":{"date-parts":[[2006,4,21]]},"reference":[{"key":"2023012409214930500_b1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/s10038-003-0079-2","article-title":"Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss","volume":"48","author":"Abe","year":"2003","journal-title":"J Hum. 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