{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:32:46Z","timestamp":1777451566534,"version":"3.51.4"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: High-throughput screening (HTS) plays a central role in modern drug discovery, allowing for testing of &amp;gt;100 000 compounds per screen. The aim of our work was to develop and implement methods for minimizing the impact of systematic error in the analysis of HTS data. To the best of our knowledge, two new data correction methods included in HTS-Corrector are not available in any existing commercial software or freeware.<\/jats:p>\n               <jats:p>Results: This paper describes HTS-Corrector, a software application for the analysis of HTS data, detection and visualization of systematic error, and corresponding correction of HTS signals. Three new methods for the statistical analysis and correction of raw HTS data are included in HTS-Corrector: background evaluation, well correction and hit-sigma distribution procedures intended to minimize the impact of systematic errors. We discuss the main features of HTS-Corrector and demonstrate the benefits of the algorithms.<\/jats:p>\n               <jats:p>Availability: The Microsoft Windows version and a detailed description of the software are freely available at the following URL:<\/jats:p>\n               <jats:p>Contact: \u00a0makarenkov.vladimir@uqam.ca<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl126","type":"journal-article","created":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T00:24:30Z","timestamp":1144196670000},"page":"1408-1409","source":"Crossref","is-referenced-by-count":40,"title":["HTS-Corrector: software for the statistical analysis and correction of experimental high-throughput screening data"],"prefix":"10.1093","volume":"22","author":[{"given":"Vladimir","family":"Makarenkov","sequence":"first","affiliation":[{"name":"Departement d'informatique, Universit\u00e9 du Qu\u00e9bec \u00e0 Montreal 1 \u00a0 1 \u00a0 \u00a0 C.P.8888, suc.Centre-Ville, Montreal, QC, H3C 3P8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmytro","family":"Kevorkov","sequence":"additional","affiliation":[{"name":"Departement d'informatique, Universit\u00e9 du Qu\u00e9bec \u00e0 Montreal 1 \u00a0 1 \u00a0 \u00a0 C.P.8888, suc.Centre-Ville, Montreal, QC, H3C 3P8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Zentilli","sequence":"additional","affiliation":[{"name":"Departement d'informatique, Universit\u00e9 du Qu\u00e9bec \u00e0 Montreal 1 \u00a0 1 \u00a0 \u00a0 C.P.8888, suc.Centre-Ville, Montreal, QC, H3C 3P8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Gagarin","sequence":"additional","affiliation":[{"name":"Departement d'informatique, Universit\u00e9 du Qu\u00e9bec \u00e0 Montreal 1 \u00a0 1 \u00a0 \u00a0 C.P.8888, suc.Centre-Ville, Montreal, QC, H3C 3P8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Malo","sequence":"additional","affiliation":[{"name":"McGill University and Genome Quebec Innovation Centre 2 \u00a0 2 \u00a0 \u00a0 740 Dr Penfield, Montreal, QC, H3A 1A4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Nadon","sequence":"additional","affiliation":[{"name":"McGill University and Genome Quebec Innovation Centre 2 \u00a0 2 \u00a0 \u00a0 740 Dr Penfield, Montreal, QC, H3A 1A4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,4,4]]},"reference":[{"key":"2023012408403988800_b1","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1177\/1087057103258285","article-title":"Improved statistical methods for hit selection in high-throughput screening","volume":"8","author":"Brideau","year":"2003","journal-title":"J. Biomol. Screen."},{"key":"2023012408403988800_b2","article-title":"Comparison of two methods for detecting and correcting systematic error in HTS data","author":"Gagarin","year":"2006"},{"key":"2023012408403988800_b3","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1177\/1087057103258284","article-title":"Statistical and graphical methods for quality control determination of HTS data","volume":"8","author":"Gunter","year":"2003","journal-title":"J. Biomol. 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