{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:50:42Z","timestamp":1759161042045},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Finding the genes involved in complex diseases susceptibility and among those genes, localizing the variant sites explaining this susceptibility is a major goal of genetic epidemiology. In this context, haplotypic methods that use the joint information on several markers may be of particular interest. When the number of haplotypes is large, a grouping may be required. Phylogenetic trees allow such groupings of haplotypes based on their evolutionary history and may help in the detection and localization of disease susceptibility sites. In this paper, we present a new software to perform phylogeny-based association and localization analysis.<\/jats:p>\n               <jats:p>Availability: The software package, including all documentation and example files, is freely available at . It is distributed under the GPL license.<\/jats:p>\n               <jats:p>Contact: \u00a0bardel@vjf.inserm.fr<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl131","type":"journal-article","created":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T00:24:30Z","timestamp":1144196670000},"page":"1402-1403","source":"Crossref","is-referenced-by-count":6,"title":["ALTree: association detection and localization of susceptibility sites using haplotype phylogenetic trees"],"prefix":"10.1093","volume":"22","author":[{"given":"Claire","family":"Bardel","sequence":"first","affiliation":[{"name":"Unit\u00e9 de recherche en G\u00e9n\u00e9tique \u00c9pid\u00e9miologique et Structure des Populations Humaines, INSERM U535 1 \u00a0 1 \u00a0 \u00a0 Villejuif, France"}]},{"given":"Vincent","family":"Danjean","sequence":"additional","affiliation":[{"name":"Laboratoire ID-IMAG, UMR 5132 2 \u00a0 2 \u00a0 \u00a0 Grenoble, France"}]},{"given":"Emmanuelle","family":"G\u00e9nin","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de recherche en G\u00e9n\u00e9tique \u00c9pid\u00e9miologique et Structure des Populations Humaines, INSERM U535 1 \u00a0 1 \u00a0 \u00a0 Villejuif, France"}]}],"member":"286","published-online":{"date-parts":[[2006,4,4]]},"reference":[{"key":"2023012408401104200_b1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/sj.ejhg.5200619","article-title":"Haplotypes vs single marker linkage disequilibrium tests: what do we gain?","volume":"9","author":"Akey","year":"2001","journal-title":"Eur. 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