{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T02:08:45Z","timestamp":1721268525750},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Potassium channels are mainly known for their role in regulating and maintaining the membrane potential. Since this is one of the key mechanisms of signal transduction, malfunction of these potassium channels leads to a wide variety of severe diseases. Thus potassium channels are priority targets of research for new drugs, despite the fact that this protein family is highly variable and closely related to other channels, which makes it very difficult to identify new types of potassium channel sequences.<\/jats:p>\n               <jats:p>Results: Here we present a new method for identifying potassium channel sequences (PSM, Property Signature Method), which\u2014in contrast to the known methods for protein classification\u2014is directly based on physicochemical properties of amino acids rather than on the amino acids themselves. A signature for the pore region including the selectivity filter has been created, representing the most common physicochemical properties of known potassium channels. This string enables genome-wide screening for sequences with similar features despite a very low degree of amino acid similarity within a protein family.<\/jats:p>\n               <jats:p>Availability: The PSM software will be made available on request from the corresponding author.<\/jats:p>\n               <jats:p>Contact: \u00a0Burkhard.Heil@gmail.com<\/jats:p>\n               <jats:p>Supplementary information: Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl132","type":"journal-article","created":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T00:24:30Z","timestamp":1144196670000},"page":"1562-1568","source":"Crossref","is-referenced-by-count":8,"title":["Computational recognition of potassium channel sequences"],"prefix":"10.1093","volume":"22","author":[{"given":"Burkhard","family":"Heil","sequence":"first","affiliation":[{"name":"Universit\u00e4t Bonn, IZMB 1 \u00a0 1 \u00a0 \u00a0 Kirschallee 1, 53115 Bonn, Germany"}]},{"given":"Jost","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Bonn, IZMB 1 \u00a0 1 \u00a0 \u00a0 Kirschallee 1, 53115 Bonn, Germany"}]},{"given":"Hella","family":"Lichtenberg-Frat\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Bonn, IZMB 1 \u00a0 1 \u00a0 \u00a0 Kirschallee 1, 53115 Bonn, Germany"}]},{"given":"Thomas","family":"Lengauer","sequence":"additional","affiliation":[{"name":"Max Planck Institut f\u00fcr Informatik, Stuhlsatzenhausweg 85 2 \u00a0 2 \u00a0 \u00a0 66123 Saarbr\u00fccken, Germany"}]}],"member":"286","published-online":{"date-parts":[[2006,4,4]]},"reference":[{"key":"2023012408342208100_b1","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"2023012408342208100_b2","volume-title":"Ion Channels and Diseases","author":"Ashcroft","year":"2000","edition":"2nd edn"},{"key":"2023012408342208100_b3","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1093\/nar\/25.1.212","article-title":"The PRINTS protein fingerprint database: functional and evolutionary applications","volume":"25","author":"Attwood","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"2023012408342208100_b4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/nar\/28.1.45","article-title":"The Swiss-Prot protein sequence database and its supplement TrEMBL in 2000","volume":"28","author":"Bairoch","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"2023012408342208100_b5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF02989802","article-title":"The effect of ATP-sensitive K+ channels on the electrical burst activity and insulin secretion in pancreatic beta-cells","volume":"17","author":"Chay","year":"1990","journal-title":"Cell Biophys."},{"key":"2023012408342208100_b6","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0014-5793(03)01104-9","article-title":"Potassium channels","volume":"555","author":"Choe","year":"2003","journal-title":"FEBS Lett."},{"key":"2023012408342208100_b7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1126\/science.280.5360.69","article-title":"The structure of the potassium channel: molecular basis of K+ conduction and selectivity","volume":"280","author":"Doyle","year":"1998","journal-title":"Science"},{"key":"2023012408342208100_b8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/(SICI)1098-1004(200001)15:1<57::AID-HUMU12>3.0.CO;2-G","article-title":"Online Mendelian Inheritance in Man (OMIM)","volume":"15","author":"Hamosh","year":"2000","journal-title":"Hum. 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