{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T17:51:26Z","timestamp":1775325086745,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sumary: Two Sample Logo is a web-based tool that detects and displays statistically significant differences in position-specific symbol compositions between two sets of multiple sequence alignments. In a typical scenario, two groups of aligned sequences will share a common motif but will differ in their functional annotation. The inclusion of the background alignment provides an appropriate underlying amino acid or nucleotide distribution and addresses intersite symbol correlations. In addition, the difference detection process is sensitive to the sizes of the aligned groups. Two Sample Logo extends WebLogo, a widely-used sequence logo generator. The source code is distributed under the MIT Open Source license agreement and is available for download free of charge.<\/jats:p>\n               <jats:p>Availability: \u00a0<\/jats:p>\n               <jats:p>Contact: \u00a0predrag@indiana.edu<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl151","type":"journal-article","created":{"date-parts":[[2006,4,22]],"date-time":"2006-04-22T00:27:33Z","timestamp":1145665653000},"page":"1536-1537","source":"Crossref","is-referenced-by-count":503,"title":["Two Sample Logo: a graphical representation of the differences between two sets of sequence alignments"],"prefix":"10.1093","volume":"22","author":[{"given":"Vladimir","family":"Vacic","sequence":"first","affiliation":[{"name":"Computer Science and Engineering Department, University of California 1 \u00a0 1 \u00a0 \u00a0 Riverside, CA, USA"}]},{"given":"Lilia M.","family":"Iakoucheva","sequence":"additional","affiliation":[{"name":"Laboratory of Statistical Genetics, The Rockefeller University 2 \u00a0 2 \u00a0 \u00a0 New York, NY, USA"}]},{"given":"Predrag","family":"Radivojac","sequence":"additional","affiliation":[{"name":"School of Informatics, Indiana University 3 \u00a0 3 \u00a0 \u00a0 Bloomington, IN, USA"}]}],"member":"286","published-online":{"date-parts":[[2006,4,21]]},"reference":[{"key":"2023012408413743100_b1","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1101\/gr.849004","article-title":"WebLogo: a sequence logo generator","volume":"14","author":"Crooks","year":"2004","journal-title":"Genome Res."},{"key":"2023012408413743100_b2","doi-asserted-by":"crossref","first-page":"13744","DOI":"10.1073\/pnas.0401881101","article-title":"Kinase peptide specificity: improved determination and relevance to protein phosphorylation","volume":"101","author":"Fujii","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2023012408413743100_b3","first-page":"583","article-title":"Displaying the information contents of structural RNA alignments: the structure logos","volume":"13","author":"Gorodkin","year":"1997","journal-title":"Comput. Appl. Biosci."},{"key":"2023012408413743100_b4","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1093\/nar\/29.13.2850","article-title":"Genome-wide detection of alternative splicing in expressed sequences of human genes","volume":"29","author":"Modrek","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"2023012408413743100_b5","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1142\/S0129183102003796","article-title":"HS3D, a dataset of Homo sapiens splice regions and its extraction procedure from a major public database","volume":"13","author":"Pollastro","year":"2002","journal-title":"Int. J. Mod. Phys."},{"key":"2023012408413743100_b6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/protein\/12.2.85","article-title":"Twilight zone of protein sequence alignments","volume":"12","author":"Rost","year":"1999","journal-title":"Protein Eng."},{"key":"2023012408413743100_b7","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1093\/nar\/18.20.6097","article-title":"Sequence logos: a new way to display consensus sequences","volume":"18","author":"Schneider","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"2023012408413743100_b8","doi-asserted-by":"crossref","first-page":"W389","DOI":"10.1093\/nar\/gki439","article-title":"enoLOGOS: a versatile web tool for energy normalized sequence logos","volume":"33","author":"Workman","year":"2005","journal-title":"Nucleic Acids Res."}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/22\/12\/1536\/48839376\/bioinformatics_22_12_1536.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/22\/12\/1536\/48839376\/bioinformatics_22_12_1536.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T08:43:24Z","timestamp":1674549804000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/22\/12\/1536\/207720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,21]]},"references-count":8,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,6,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btl151","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2006,6,15]]},"published":{"date-parts":[[2006,4,21]]}}}