{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:52:14Z","timestamp":1761292334016},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Tools and resources for translating the remarkable growth witnessed in recent years in the number of protein structures determined experimentally into actual gain in the functional coverage of the proteome are becoming increasingly necessary. We introduce FCP, a publicly accessible web tool dedicated to analyzing the current state and trends of the population of structures within protein families. FCP offers both graphical and quantitative data on the degree of functional coverage of enzymes and nuclear receptors by existing structures, as well as on the bias observed in the distribution of structures along their respective functional classification schemes.<\/jats:p>\n               <jats:p>Availability: \u00a0<\/jats:p>\n               <jats:p>Contact: \u00a0jmestres@imim.es<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl188","type":"journal-article","created":{"date-parts":[[2006,5,17]],"date-time":"2006-05-17T01:22:38Z","timestamp":1147828958000},"page":"1792-1793","source":"Crossref","is-referenced-by-count":14,"title":["FCP: functional coverage of the proteome by structures"],"prefix":"10.1093","volume":"22","author":[{"given":"Ricard","family":"Garc\u00eda-Serna","sequence":"first","affiliation":[{"name":"Chemogenomics Laboratory, Research Unit on Biomedical Informatics \u00a0 Institut Municipal d'Investigaci\u00f3 M\u00e8dica and Universitat Pompeu Fabra, Dr Aiguader 88, 08003 Barcelona, Catalonia, Spain"}]},{"given":"Lulla","family":"Opatowski","sequence":"additional","affiliation":[{"name":"Chemogenomics Laboratory, Research Unit on Biomedical Informatics \u00a0 Institut Municipal d'Investigaci\u00f3 M\u00e8dica and Universitat Pompeu Fabra, Dr Aiguader 88, 08003 Barcelona, Catalonia, Spain"}]},{"given":"Jordi","family":"Mestres","sequence":"additional","affiliation":[{"name":"Chemogenomics Laboratory, Research Unit on Biomedical Informatics \u00a0 Institut Municipal d'Investigaci\u00f3 M\u00e8dica and Universitat Pompeu Fabra, Dr Aiguader 88, 08003 Barcelona, Catalonia, Spain"}]}],"member":"286","published-online":{"date-parts":[[2006,5,15]]},"reference":[{"key":"2023012409010215500_b1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/nar\/28.1.304","article-title":"The ENZYME database in 2000","volume":"28","author":"Bairoch","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"2023012409010215500_b2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"2023012409010215500_b3","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nrg1317","article-title":"Chemogenomics: an emerging strategy for rapid target and drug discovery","volume":"5","author":"Bredel","year":"2004","journal-title":"Nat. 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