{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:40:46Z","timestamp":1759938046529},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: The Heart and Calcium functional Network (HCNet) database is a collection of functional gene modules calculated from the microarray data compendium available from the GEO database. It is a specialized database designed to assist experimentalists for cardiac calcium signaling research by providing the pre-calculated gene clusters and their potential correlation network in heart.<\/jats:p>\n               <jats:p>In the current release of HCNet, 57 functional modules from 786 target genes obtained by a bi-clustering analysis of 381 microarray datasets are available. Detailed information of the clusters such as expression profiles, network diagrams is provided in two categories, heart-specific genes and heart-specific genes along with calcium toolkit genes. Overrepresented gene ontological categories and transcription factors in each cluster are also provided to infer the biological implications of the detected functional modules.<\/jats:p>\n               <jats:p>Availability: HCNet is available at<\/jats:p>\n               <jats:p>Contact: \u00a0dhkim@gist.ac.kr<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl331","type":"journal-article","created":{"date-parts":[[2006,6,21]],"date-time":"2006-06-21T03:47:02Z","timestamp":1150861622000},"page":"2053-2054","source":"Crossref","is-referenced-by-count":8,"title":["HCNet: a database of heart and calcium functional network"],"prefix":"10.1093","volume":"22","author":[{"given":"Seong-Eui","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Life Science, Gwangju Institute of Science and Technology 1 \u00a0 1 \u00a0 \u00a0 1 Oryong-dong, Buk-gu, Gwangju 500-712, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Hwan","family":"Rho","sequence":"additional","affiliation":[{"name":"Department of Life Science, Gwangju Institute of Science and Technology 1 \u00a0 1 \u00a0 \u00a0 1 Oryong-dong, Buk-gu, Gwangju 500-712, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Il","family":"Yeom","sequence":"additional","affiliation":[{"name":"Laboratory of Human Genomics, Korea Research Institute of Bioscience and Biotechnology 2 \u00a0 2 \u00a0 \u00a0 Deajeon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Han","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Life Science, Gwangju Institute of Science and Technology 1 \u00a0 1 \u00a0 \u00a0 1 Oryong-dong, Buk-gu, Gwangju 500-712, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,6,20]]},"reference":[{"key":"2023012409102341100_b1","doi-asserted-by":"crossref","first-page":"D562","DOI":"10.1093\/nar\/gki022","article-title":"NCBI GEO: mining millions of expression profiles\u2014database and tools","volume":"33","author":"Barrett","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"2023012409102341100_b2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm1155","article-title":"Calcium signalling: dynamics, homeostasis and remodelling","volume":"4","author":"Berridge","year":"2003","journal-title":"Nat. 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Biotechnol."}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/22\/16\/2053\/48838961\/bioinformatics_22_16_2053.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/22\/16\/2053\/48838961\/bioinformatics_22_16_2053.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T09:43:34Z","timestamp":1674553414000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/22\/16\/2053\/208452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,20]]},"references-count":8,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2006,8,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btl331","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2006,8,15]]},"published":{"date-parts":[[2006,6,20]]}}}