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A lack of a convenient interface has been an additional obstacle for easy usage.<\/jats:p>\n                  <jats:p>Results: ANM has been evaluated on a large set of proteins to establish the optimal model parameters that achieve the highest correlation with experimental data and its limits of accuracy and applicability. Residue fluctuations in globular proteins are shown to be more accurately predicted than those in nonglobular proteins, and core residues are more accurately described than solvent-exposed ones. Significant improvement in agreement with experiments is observed with increase in the resolution of the examined structure. A new server for ANM calculations is presented, which offers flexible options for controlling model parameters and output formats, interactive animation of collective modes and advanced graphical features.<\/jats:p>\n                  <jats:p>Availability: ANM server ()<\/jats:p>\n                  <jats:p>Contact: \u00a0bahar@ccbb.pitt.edu<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl448","type":"journal-article","created":{"date-parts":[[2006,8,23]],"date-time":"2006-08-23T20:25:54Z","timestamp":1156364754000},"page":"2619-2627","source":"Crossref","is-referenced-by-count":296,"title":["Anisotropic network model: systematic evaluation and a new web interface"],"prefix":"10.1093","volume":"22","author":[{"given":"Eran","family":"Eyal","sequence":"first","affiliation":[{"name":"Department of Computational Biology, School of Medicine, University of Pittsburgh \u00a0 PA 15213, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee-Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, School of Medicine, University of Pittsburgh \u00a0 PA 15213, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivet","family":"Bahar","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, School of Medicine, University of Pittsburgh \u00a0 PA 15213, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,8,23]]},"reference":[{"key":"2023012408434744300_b1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1110\/ps.04882105","article-title":"Normal modes for predicting protein motions: a comprehensive database assessment and associated web tool","volume":"14","author":"Alexandrov","year":"2005","journal-title":"Protein Sci."},{"key":"2023012408434744300_b2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0006-3495(01)76033-X","article-title":"Anisotropy of fluctuation dynamics of proteins with an elastic network model","volume":"80","author":"Atilgan","year":"2001","journal-title":"Biophys. 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