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Tropical allows the investigation of systems with an inhomogeneous distribution of molecules, making it well suited for quantitative analyses of microscopy experiments such as fluorescence recovery after photobleaching (FRAP).<\/jats:p>\n               <jats:p>Availability: Tropical is available free of charge for academic use at after signing a material transfer agreement.<\/jats:p>\n               <jats:p>Contact: \u00a0r.eils@dkfz.de<\/jats:p>\n               <jats:p>Supplementary information: \u00a0<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl456","type":"journal-article","created":{"date-parts":[[2006,8,30]],"date-time":"2006-08-30T08:21:24Z","timestamp":1156926084000},"page":"2709-2710","source":"Crossref","is-referenced-by-count":11,"title":["Tropical\u2014parameter estimation and simulation of reaction\u2013diffusion models based on spatio-temporal microscopy images"],"prefix":"10.1093","volume":"22","author":[{"given":"Markus","family":"Ulrich","sequence":"first","affiliation":[{"name":"Department of Theoretical Bioinformatics, German Cancer Research Center 1 \u00a0 1 \u00a0 \u00a0 Im Neuenheimer Feld 580, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantin","family":"Kappel","sequence":"additional","affiliation":[{"name":"Department of Theoretical Bioinformatics, German Cancer Research Center 1 \u00a0 1 \u00a0 \u00a0 Im Neuenheimer Feld 580, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Beaudouin","sequence":"additional","affiliation":[{"name":"Department of Theoretical Bioinformatics, German Cancer Research Center 1 \u00a0 1 \u00a0 \u00a0 Im Neuenheimer Feld 580, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Hezel","sequence":"additional","affiliation":[{"name":"Department of Theoretical Bioinformatics, German Cancer Research Center 1 \u00a0 1 \u00a0 \u00a0 Im Neuenheimer Feld 580, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Theoretical Bioinformatics, German Cancer Research Center 1 \u00a0 1 \u00a0 \u00a0 Im Neuenheimer Feld 580, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Eils","sequence":"additional","affiliation":[{"name":"Department of Theoretical Bioinformatics, German Cancer Research Center 1 \u00a0 1 \u00a0 \u00a0 Im Neuenheimer Feld 580, 69120 Heidelberg, Germany"},{"name":"Institute for Pharmacy and Molecular Biotechnology, University of Heidelberg 2 \u00a0 2 \u00a0 \u00a0 Im Neuenheimer Feld 364, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,8,29]]},"reference":[{"key":"2023012408432609900_b1","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1529\/biophysj.105.071241","article-title":"Dissecting the contribution of diffusion and interactions to the mobility of nuclear proteins","volume":"90","author":"Beaudouin","year":"2006","journal-title":"Biophys. 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