{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T09:01:25Z","timestamp":1693558885053},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,10,1]]},"abstract":"Abstract<\/jats:title>Summary: Low-coverage genomes (LCGs) are becoming an increasingly important source of data for phylogenetic studies. However, assembly of these genomes is time consuming, difficult and lags behind sequence generation. THOR is a fast, stringent application for targeted reconstruction of sequence orthologs in unassembled LCGs. Using a 4\u00d7 coverage set of mouse whole-genome sequence reads, THOR could partially or completely reconstruct 416\/1000 human promoter ortholog regions in \u223c7.3 min\/promoter. THOR's reconstruction rate improves markedly with both higher-coverage, and less divergent target species.<\/jats:p>Availability: THOR is implemented in java and is currently available as source code and as a web service (www.bcgsc.ca\/services\/thor) for reconstructing human sequences.<\/jats:p>Contact: matthewb@bcgsc.ca<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl513","type":"journal-article","created":{"date-parts":[[2006,10,13]],"date-time":"2006-10-13T07:47:15Z","timestamp":1160725635000},"page":"2622-2624","source":"Crossref","is-referenced-by-count":7,"title":["THOR: targeted high-throughput ortholog reconstructor"],"prefix":"10.1093","volume":"23","author":[{"given":"Matthew N.","family":"Bainbridge","sequence":"first","affiliation":[{"name":"British Columbia Cancer Agency (BCCA) Genome Sciences Centre, 675 West 10th Avenue, Vancouver, BC, Canada"}]},{"given":"Ren\u00e9 L.","family":"Warren","sequence":"additional","affiliation":[{"name":"British Columbia Cancer Agency (BCCA) Genome Sciences Centre, 675 West 10th Avenue, Vancouver, BC, Canada"}]},{"given":"An","family":"He","sequence":"additional","affiliation":[{"name":"British Columbia Cancer Agency (BCCA) Genome Sciences Centre, 675 West 10th Avenue, Vancouver, BC, Canada"}]},{"given":"Mikhail","family":"Bilenky","sequence":"additional","affiliation":[{"name":"British Columbia Cancer Agency (BCCA) Genome Sciences Centre, 675 West 10th Avenue, Vancouver, BC, Canada"}]},{"given":"A. 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