{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T12:04:13Z","timestamp":1722686653543},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: There is much local variation in recombination rates across the human genome\u2014with the majority of recombination occuring in recombination hotspots\u2014short regions of around \u223c2 kb in length that have much higher recombination rates than neighbouring regions. Knowledge of this local variation is important, e.g. in the design and analysis of association studies for disease genes. Population genetic data, such as that generated by the HapMap project, can be used to infer the location of these hotspots. We present a new, efficient and powerful method for detecting recombination hotspots from population data.<\/jats:p>\n               <jats:p>Results: We compare our method with four current methods for detecting hotspots. It is orders of magnitude quicker, and has greater power, than two related approaches. It appears to be more powerful than HotspotFisher, though less accurate at inferring the precise positions of the hotspot. It was also more powerful than LDhot in some situations: particularly for weaker hotspots (10\u201340 times the background rate) when SNP density is lower (&amp;lt; 1\/kb).<\/jats:p>\n               <jats:p>Availability: Program, data sets, and full details of results are available at:<\/jats:p>\n               <jats:p>Contact: \u00a0p.fearnhead@lancs.ac.uk<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl540","type":"journal-article","created":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T14:16:03Z","timestamp":1161699363000},"page":"3061-3066","source":"Crossref","is-referenced-by-count":61,"title":["SequenceLDhot: detecting recombination hotspots"],"prefix":"10.1093","volume":"22","author":[{"given":"Paul","family":"Fearnhead","sequence":"first","affiliation":[{"name":"Department of Mathematics and Statistics, Lancaster University \u00a0 Lancaster LA1 4YF, UK"}]}],"member":"286","published-online":{"date-parts":[[2006,10,23]]},"reference":[{"key":"2023012408493621200_b1","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/ng1376","article-title":"Evidence for substantial fine-scale variation in recombination rates across the human genome","volume":"36","author":"Crawford","year":"2004","journal-title":"Nat. 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