{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:58:49Z","timestamp":1761512329335},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Summary: The scale of genetic-variation datasets has increased enormously and the linkage equilibrium (LD) structure of these polymorphisms, particularly in whole-genome association studies, is of great interest. The significant computational complexity of calculating single- and multiple-marker correlations at a genome-wide scale remains challenging. We have developed a program that efficiently characterizes whole-genome LD structure on large number of SNPs in terms of single- and multiple-marker correlations.<\/jats:p><jats:p>Availability: LdCompare is licensed under the GNU General Public License (GPL). Source code, documentation, testing datasets and precompiled executables are available for download at:<\/jats:p><jats:p>Contact: \u00a0ke_hao@affymetrix.com<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl574","type":"journal-article","created":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T05:43:59Z","timestamp":1165383839000},"page":"252-254","source":"Crossref","is-referenced-by-count":26,"title":["LdCompare: rapid computation of single- and multiple-marker<i>r<\/i>2 and genetic coverage"],"prefix":"10.1093","volume":"23","author":[{"given":"K.","family":"Hao","sequence":"first","affiliation":[]},{"given":"X.","family":"Di","sequence":"additional","affiliation":[]},{"given":"S.","family":"Cawley","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2006,12,5]]},"reference":[{"key":"2023041107041902100_","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nature04226","article-title":"A haplotype map of the human genome","volume":"437","author":"Altshuler","year":"2005","journal-title":"Nature"},{"key":"2023041107041902100_","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of ld and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"2023041107041902100_","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1086\/381000","article-title":"Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium","volume":"74","author":"Carlson","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"2023041107041902100_","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/ng1669","article-title":"Efficiency and power in genetic association studies","volume":"37","author":"De bakker","year":"2005","journal-title":"Nat. Genet."},{"key":"2023041107041902100_","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1093\/bioinformatics\/bti442","article-title":"Ls-snp: large-scale annotation of coding non-synonymous snps based on multiple information sources","volume":"21","author":"Karchin","year":"2005","journal-title":"Bioinformatics"},{"key":"2023041107041902100_","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1086\/500808","article-title":"A comparison of phasing algorithms for trios and unrelated individuals","volume":"78","author":"Marchini","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"2023041107041902100_","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1086\/427925","article-title":"Linkage disequilibrium patterns and tagsnp transferability among european populations","volume":"76","author":"Mueller","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"2023041107041902100_","first-page":"663","article-title":"Evaluating and improving power in whole genome association studies using fixed marker sets","volume-title":"Nat. Genet.","author":"Pe'er","year":"2006"},{"key":"2023041107041902100_","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nrg1522","article-title":"Genome-wide association studies: theoretical and practical concerns","volume":"6","author":"Wang","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"2023041107041902100_","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.taap.2004.09.024","article-title":"Single nucleotide polymorphism in transcriptional regulatory regions and expression of environmentally responsive genes","volume":"207","author":"Wang","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2023041107041902100_","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/gepi.20131","article-title":"Tag snp selection for finnish individuals based on the ceph utah hapmap database","volume":"30","author":"Willer","year":"2006","journal-title":"Genet. Epidemiol."}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/23\/2\/252\/49820470\/bioinformatics_23_2_252.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/23\/2\/252\/49820470\/bioinformatics_23_2_252.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T22:01:04Z","timestamp":1683669664000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/23\/2\/252\/205254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,5]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,1,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btl574","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2007,1,15]]},"published":{"date-parts":[[2006,12,5]]}}}