{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T01:03:44Z","timestamp":1770339824345,"version":"3.49.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Summary: Assessment of potential allergenicity and patterns of cross-reactivity is necessary whenever novel proteins are introduced into human food chain. Current bioinformatic methods in allergology focus mainly on the prediction of allergenic proteins, with no information on cross-reactivity patterns among known allergens. In this study, we present AllerTool, a web server with essential tools for the assessment of predicted as well as published cross-reactivity patterns of allergens. The analysis tools include graphical representation of allergen cross-reactivity information; a local sequence comparison tool that displays information of known cross-reactive allergens; a sequence similarity search tool for assessment of cross-reactivity in accordance to FAO\/WHO Codex alimentarius guidelines; and a method based on support vector machine (SVM). A 10-fold cross-validation results showed that the area under the receiver operating curve (AROC) of SVM models is 0.90 with 86.00% sensitivity (SE) at specificity (SP) of 86.00%.<\/jats:p><jats:p>Availability: AllerTool is freely available at<\/jats:p><jats:p>Contact: \u00a0zhzhang@i2r.a-star.edu.sg<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl621","type":"journal-article","created":{"date-parts":[[2006,12,7]],"date-time":"2006-12-07T01:14:12Z","timestamp":1165454052000},"page":"504-506","source":"Crossref","is-referenced-by-count":38,"title":["AllerTool: a web server for predicting allergenicity and allergic cross-reactivity in proteins"],"prefix":"10.1093","volume":"23","author":[{"given":"Zong Hong","family":"Zhang","sequence":"first","affiliation":[]},{"given":"Judice L. Y.","family":"Koh","sequence":"additional","affiliation":[]},{"given":"Guang Lan","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Khar Heng","family":"Choo","sequence":"additional","affiliation":[]},{"given":"Martti T.","family":"Tammi","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, National University of Singapore 1 \u00a0 1 \u00a0 \u00a0 14 Science Drive 4, Singapore 117543"}]},{"given":"Joo Chuan","family":"Tong","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2006,12,6]]},"reference":[{"key":"2023041109270061700_","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"2023041109270061700_","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/bioinformatics\/bth477","article-title":"Supervised identification of allergen-representative peptides for in silico detection of potentially allergenic proteins","volume":"21","author":"Bjorklund","year":"2005","journal-title":"Bioinformatics"},{"key":"2023041109270061700_","article-title":"Computer prediction of allergen proteins from sequence-derived protein structural and physicochemical properties","author":"Cui","year":"2006","journal-title":"Mol. 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