{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T04:36:54Z","timestamp":1771043814369,"version":"3.50.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Motivation: Efficient fitting tools are needed to take advantage of a fast growth of atomic models of protein domains from crystallography or comparative modeling, and low-resolution density maps of larger molecular assemblies. Here, we report a novel fitting algorithm for the exhaustive and fast overlay of partial high-resolution models into a low-resolution density map. The method incorporates a fast rotational search based on spherical harmonics (SH) combined with a simple translational scanning.<\/jats:p><jats:p>Results: This novel combination makes it possible to accurately dock atomic structures into low-resolution electron-density maps in times ranging from seconds to a few minutes. The high-efficiency achieved with simulated and experimental test cases preserves the exhaustiveness needed in these heterogeneous-resolution merging tools. The results demonstrate its efficiency, robustness and high-throughput coverage.<\/jats:p><jats:p>Availability: \u00a0<\/jats:p><jats:p>Contact: \u00a0pablo@cib.csic.es<\/jats:p><jats:p>Supplementary information: Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl625","type":"journal-article","created":{"date-parts":[[2006,12,7]],"date-time":"2006-12-07T01:14:12Z","timestamp":1165454052000},"page":"427-433","source":"Crossref","is-referenced-by-count":88,"title":["ADP_EM: fast exhaustive multi-resolution docking for high-throughput coverage"],"prefix":"10.1093","volume":"23","author":[{"given":"Jos\u00e9 Ignacio","family":"Garz\u00f3n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, The Scripps Research Institute La Jolla 1 \u00a0 1 \u00a0 \u00a0 CA 92037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben","family":"Abagyan","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, The Scripps Research Institute La Jolla 1 \u00a0 1 \u00a0 \u00a0 CA 92037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Chac\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,12,6]]},"reference":[{"key":"2023041109265535100_","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.sbi.2004.03.007","article-title":"RNA polymerase II structure, and organization of the preinitiation complex","volume":"14","author":"Asturias","year":"2004","journal-title":"Curr. 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