{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T20:56:15Z","timestamp":1761944175086,"version":"build-2065373602"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Summary: The increasing size and complexity of biological databases has led to a growing trend to federate rather than duplicate them. In order to share data between federated databases, protocols for the exchange mechanism must be developed. One such data exchange protocol that is widely used is the Distributed Annotation System (DAS). For example, DAS has enabled small experimental groups to integrate their data into the Ensembl genome browser. We have developed ProServer, a simple, lightweight, Perl-based DAS server that does not depend on a separate HTTP server. The ProServer package is easily extensible, allowing data to be served from almost any underlying data model. Recent additions to the DAS protocol have enabled both structure and alignment (sequence and structural) data to be exchanged. ProServer allows both of these data types to be served.<\/jats:p><jats:p>Availability: ProServer can be downloaded from http:\/\/www.sanger.ac.uk\/proserver\/ or CPAN http:\/\/search.cpan.org\/~rpettett\/. Details on the system requirements and installation of ProServer can be found at http:\/\/www.sanger.ac.uk\/proserver\/.<\/jats:p><jats:p>Contact: \u00a0rmp@sanger.ac.uk<\/jats:p><jats:p>Supplementary Materials: DasClientExamples.pdf<\/jats:p>","DOI":"10.1093\/bioinformatics\/btl650","type":"journal-article","created":{"date-parts":[[2007,1,20]],"date-time":"2007-01-20T01:12:50Z","timestamp":1169255570000},"page":"1568-1570","source":"Crossref","is-referenced-by-count":27,"title":["ProServer: a simple, extensible Perl DAS server"],"prefix":"10.1093","volume":"23","author":[{"given":"Robert D.","family":"Finn","sequence":"first","affiliation":[{"name":"Wellcome Trust Sanger Institute, Wellcome Trust Geome Campus, Hinxton, Cambridge, CB10 1SA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James W.","family":"Stalker","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Wellcome Trust Geome Campus, Hinxton, Cambridge, CB10 1SA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David K.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Wellcome Trust Geome Campus, Hinxton, Cambridge, CB10 1SA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Kulesha","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Wellcome Trust Geome Campus, Hinxton, Cambridge, CB10 1SA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jody","family":"Clements","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Wellcome Trust Geome Campus, Hinxton, Cambridge, CB10 1SA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Pettett","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Wellcome Trust Geome Campus, Hinxton, Cambridge, CB10 1SA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,1,18]]},"reference":[{"key":"2023041105091794800_","doi-asserted-by":"crossref","first-page":"D556","DOI":"10.1093\/nar\/gkj133","article-title":"Ensembl 2006","volume":"34","author":"Birney","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"2023041105091794800_","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-2-7","article-title":"The distributed annotation system","volume":"2","author":"Dowell","year":"2001","journal-title":"BMC Bioinformatics"},{"key":"2023041105091794800_","doi-asserted-by":"crossref","first-page":"D247","DOI":"10.1093\/nar\/gkj149","article-title":"Pfam: clans, web tools and services","volume":"34","author":"Finn","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"2023041105091794800_","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1101\/gr.3756405","article-title":"AnoEST: Toward A. gambiae functional genomics","volume":"15","author":"Kriventseva","year":"2005","journal-title":"Genome Res"},{"key":"2023041105091794800_","doi-asserted-by":"crossref","first-page":"ii40","DOI":"10.1093\/bioinformatics\/bti1106","article-title":"Adding some SPICE to DAS","volume":"21","author":"Prlic","year":"2005","journal-title":"Bioinformatics"},{"key":"2023041105091794800_","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/11799511_17","article-title":"The Distributed Annotation System for integration of biological data","volume-title":"Data Integration in the Life Sciences: Third International Workshop, DILS 2006. 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