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The mutations that are highly correlated with phenotypic change can be ranked by score. We use these methods to find SNPs correlated with resistance to Bacillus anthracis in inbred mouse strains. Our findings are consistent with the current biological literature, and also suggest potential novel candidate genes.<\/jats:p><jats:p>Contact: \u00a0farhat@pacific.mps.ohio-state.edu for software requests.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btm003","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T01:16:30Z","timestamp":1170465390000},"page":"785-788","source":"Crossref","is-referenced-by-count":19,"title":["Large scale genotype\u2013phenotype correlation analysis based on phylogenetic trees"],"prefix":"10.1093","volume":"23","author":[{"given":"Farhat","family":"Habib","sequence":"first","affiliation":[{"name":"1 Department of Physics, 2Department of Pharmacology and 3Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Johnson","sequence":"additional","affiliation":[{"name":"1 Department of Physics, 2Department of Pharmacology and 3Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Bundschuh","sequence":"additional","affiliation":[{"name":"1 Department of Physics, 2Department of Pharmacology and 3Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Janies","sequence":"additional","affiliation":[{"name":"1 Department of Physics, 2Department of Pharmacology and 3Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,1,31]]},"reference":[{"key":"2023041108144151700_","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature01794","article-title":"Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin","volume":"424","author":"Agrawal","year":"2003","journal-title":"Nature"},{"key":"2023041108144151700_","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1086\/324069","article-title":"Genomewide scans of complex human diseases: true linkage is hard to find","volume":"69","author":"Altm\u00fceller","year":"2001","journal-title":"Am. 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