{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:33:30Z","timestamp":1762673610125},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Motivation: Observation of co-crystallized protein\u2013protein complexes and low-resolution protein\u2013protein docking studies suggest the existence of a binding-related anisotropic shape characteristic of protein\u2013protein complexes.<\/jats:p><jats:p>Results: Our study systematically assessed the global shape of proteins in a non-redundant database of co-crystallized protein\u2013protein complexes by measuring the distance of the surface residues to the protein's center of mass. The results show that on average the binding site residues are closer to the center of mass than the non-binding surface residues. Thus, the study directly detects an important and simple binding-related characteristic of protein shapes. The results provide an insight into one of the fundamental properties of protein structure and association.<\/jats:p><jats:p>Contact: \u00a0vakser@ku.edu<\/jats:p>","DOI":"10.1093\/bioinformatics\/btm018","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T01:16:30Z","timestamp":1170465390000},"page":"789-792","source":"Crossref","is-referenced-by-count":32,"title":["A simple shape characteristic of protein\u2013protein recognition"],"prefix":"10.1093","volume":"23","author":[{"given":"George","family":"Nicola","sequence":"first","affiliation":[{"name":"1 Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA and 2Center for Bioinformatics and Department of Molecular Biosciences, The University of Kansas, 2030 Becker Drive, Lawrence, KS 66047, USA"}]},{"given":"Ilya A.","family":"Vakser","sequence":"additional","affiliation":[{"name":"1 Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA and 2Center for Bioinformatics and Department of Molecular Biosciences, The University of Kansas, 2030 Becker Drive, Lawrence, KS 66047, USA"}]}],"member":"286","published-online":{"date-parts":[[2007,1,31]]},"reference":[{"key":"2023041108144036100_","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"2023041108144036100_","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1110\/ps.051759005","article-title":"Protein surface analysis for function annotation in high-throughput structural genomics pipeline","volume":"14","author":"Binkowski","year":"2005","journal-title":"Protein Sci"},{"key":"2023041108144036100_","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1110\/ps.062249106","article-title":"Residue centrality, functionally important residues, and active site shape: analysis of enzyme and non-enzyme families","volume":"15","author":"del Sol","year":"2006","journal-title":"Protein Sci"},{"key":"2023041108144036100_","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1093\/bioinformatics\/btl447","article-title":"DOCKGROUND resource for studying protein-protein interfaces","volume":"22","author":"Douguet","year":"2006","journal-title":"Bioinformatics"},{"key":"2023041108144036100_","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1073\/pnas.97.3.978","article-title":"A relation between the principal axes of inertia and ligand binding","volume":"97","author":"Foote","year":"2000","journal-title":"Proc. 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