{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T19:01:52Z","timestamp":1785351712086,"version":"3.55.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Computational models of tissue homeostasis will facilitate a deeper understanding of many diseases. They link molecular networks, cellular differentiation and the spatial and temporal organization of tissues. Here we show an approach which is able to computationally turn a healthy in silico epidermis into one with four central properties of psoriatic epidermis. We achieve this by altering a single simulation parameter in the cellular differentiation program of the simulated epidermal keratinocytes: the fractional time period during which transit amplifying cells proliferate (\u03c4). Prolonging \u03c4 results in the four main pathological characteristics of psoriatic skin: (1) an absolute increase of the germinative compartment, (2) an absolute increase of the differentiated compartment, (3) a higher proportion of germinative cells and (4) a marked reduction in turnover time. The prolongation of \u03c4 is able to increase the proliferation capacity of the epidermal tissue without altering the cell cycle frequency.<\/jats:p><jats:p>Contact: niels.grabe@med.uni-heidelberg.de<\/jats:p>","DOI":"10.1093\/bioinformatics\/btm042","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T01:05:35Z","timestamp":1171847135000},"page":"1309-1312","source":"Crossref","is-referenced-by-count":37,"title":["Simulating psoriasis by altering transit amplifying cells"],"prefix":"10.1093","volume":"23","author":[{"given":"Niels","family":"Grabe","sequence":"first","affiliation":[{"name":"1 Department of Medical Informatics, Institute of Medical Biometry and Informatics, University Hospital Heidelberg, 69120 Heidelberg, Germany and 2Department of Dermatology, University Hospital Hamburg-Eppendorf Martinistrasse 52, 20246 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Neuber","sequence":"additional","affiliation":[{"name":"1 Department of Medical Informatics, Institute of Medical Biometry and Informatics, University Hospital Heidelberg, 69120 Heidelberg, Germany and 2Department of Dermatology, University Hospital Hamburg-Eppendorf Martinistrasse 52, 20246 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,2,18]]},"reference":[{"key":"2023041104583763000_","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1046\/j.1523-1747.2001.01247.x","article-title":"A strikingly constant ratio exists between Langerhans cells and other epidermal cells in human skin. A stereologic study using the optical disector method and the confocal laser scanning microscope","volume":"116","author":"Bauer","year":"2001","journal-title":"J. Invest. Dermatol."},{"key":"2023041104583763000_","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1023\/A:1003457709690","article-title":"Epidermal cell kinetics by combining in situ hybridization and immunohistochemistry","volume":"30","author":"Castelijns","year":"1998","journal-title":"Histochem. 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