{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T02:58:30Z","timestamp":1775098710836,"version":"3.50.1"},"reference-count":4,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Here we describe an R library for genome-wide association (GWA) analysis. It implements effective storage and handling of GWA data, fast procedures for genetic data quality control, testing of association of single nucleotide polymorphisms with binary or quantitative traits, visualization of results and also provides easy interfaces to standard statistical and graphical procedures implemented in base R and special R libraries for genetic analysis. We evaluated GenABEL using one simulated and two real data sets. We conclude that GenABEL enables the analysis of GWA data on desktop computers.<\/jats:p><jats:p>Availability: \u00a0http:\/\/cran.r-project.org<\/jats:p><jats:p>Contact: \u00a0i.aoultchenko@erasmusmc.nl<\/jats:p>","DOI":"10.1093\/bioinformatics\/btm108","type":"journal-article","created":{"date-parts":[[2007,3,24]],"date-time":"2007-03-24T00:22:51Z","timestamp":1174695771000},"page":"1294-1296","source":"Crossref","is-referenced-by-count":1583,"title":["GenABEL: an R library for genome-wide association analysis"],"prefix":"10.1093","volume":"23","author":[{"given":"Yurii S.","family":"Aulchenko","sequence":"first","affiliation":[{"name":"1 Department of Epidemiology and Biostatistics, Erasmus MC Rotterdam, Postbus 2040, 3000 CA Rotterdam, The Netherlands and 2Statistical Genetics Group, Max-Planck-Institute of Psychiatry, Kraepelinstr. 10, D-80804 Munich, Germany"}]},{"given":"Stephan","family":"Ripke","sequence":"additional","affiliation":[{"name":"1 Department of Epidemiology and Biostatistics, Erasmus MC Rotterdam, Postbus 2040, 3000 CA Rotterdam, The Netherlands and 2Statistical Genetics Group, Max-Planck-Institute of Psychiatry, Kraepelinstr. 10, D-80804 Munich, Germany"}]},{"given":"Aaron","family":"Isaacs","sequence":"additional","affiliation":[{"name":"1 Department of Epidemiology and Biostatistics, Erasmus MC Rotterdam, Postbus 2040, 3000 CA Rotterdam, The Netherlands and 2Statistical Genetics Group, Max-Planck-Institute of Psychiatry, Kraepelinstr. 10, D-80804 Munich, Germany"}]},{"given":"Cornelia M.","family":"van Duijn","sequence":"additional","affiliation":[{"name":"1 Department of Epidemiology and Biostatistics, Erasmus MC Rotterdam, Postbus 2040, 3000 CA Rotterdam, The Netherlands and 2Statistical Genetics Group, Max-Planck-Institute of Psychiatry, Kraepelinstr. 10, D-80804 Munich, Germany"}]}],"member":"286","published-online":{"date-parts":[[2007,3,23]]},"reference":[{"key":"2023041104481639000_","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.tig.2006.05.001","article-title":"Genome-wide association: a promising start to a long race","volume":"22","author":"Evans","year":"2006","journal-title":"Trends Genet."},{"key":"2023041104481639000_","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/bioinformatics\/18.2.337","article-title":"Generating samples under a Wright-Fisher neutral model of genetic variation","volume":"18","author":"Hudson","year":"2002","journal-title":"Bioinformatics"},{"key":"2023041104481639000_","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1086\/338688","article-title":"Score tests for association between traits and hap lotypes when linkage phase is ambiguous","volume":"70","author":"Schaid","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"2023041104481639000_","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1086\/429864","article-title":"A note on exact tests of Hardy-Weinberg equilibrium","volume":"76","author":"Wigginton","year":"2005","journal-title":"Am. J. Hum. Genet."}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/23\/10\/1294\/49813098\/bioinformatics_23_10_1294.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/23\/10\/1294\/49813098\/bioinformatics_23_10_1294.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T04:50:14Z","timestamp":1683780614000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/23\/10\/1294\/198080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,23]]},"references-count":4,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,5,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btm108","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2007,5,15]]},"published":{"date-parts":[[2007,3,23]]}}}