{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T04:47:19Z","timestamp":1769921239327,"version":"3.49.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Functional mapping has proven to be powerful for characterizing quantitative trait loci (QTL) that control complex dynamic traits. More recently, functional mapping has been extended to identify the host QTL responsible for HIV dynamics by incorporating a parametric bi-exponential function for earlier stages of viral load trajectories. However, existing functional mapping cannot be used to map long-term HIV dynamics because no mathematical functions are available for later stages of HIV dynamic changes.<\/jats:p>\n               <jats:p>Results: We derived a statistical model for functional mapping of dynamic QTL through characterizing HIV load trajectories during a long-term period semiparametrically. The new model was constructed within the maximum likelihood framework and implemented with the EM-simplex algorithm. It allows for the test of differences in the genetic control of short- and long-term HIV dynamics and the characterization of the effects of viral-host genome interaction. Extensive simulation studies have been performed to test the statistical behavior of this model. The new model will provide an important tool for genetic and genomic studies of human complex diseases like HIV\/AIDS and their pathological progression.<\/jats:p>\n               <jats:p>Availability: Available on request from the corresponding author.<\/jats:p>\n               <jats:p>Contact: rwu@stat.ufl.edu<\/jats:p>","DOI":"10.1093\/bioinformatics\/btm164","type":"journal-article","created":{"date-parts":[[2007,7,23]],"date-time":"2007-07-23T16:13:46Z","timestamp":1185207226000},"page":"i569-i576","source":"Crossref","is-referenced-by-count":8,"title":["Semiparametric functional mapping of quantitative trait loci governing long-term HIV dynamics"],"prefix":"10.1093","volume":"23","author":[{"given":"Song","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Statistics, University of Florida, Gainesville, FL 32611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Florida, Gainesville, FL 32611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Florida, Gainesville, FL 32611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,7,1]]},"reference":[{"key":"2023062708513781800_B1","volume-title":"An Introduction to Splines for Use in Computer Graphics and Geometric Modelling","author":"Bartels","year":"1987"},{"key":"2023062708513781800_B2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/373123a0","article-title":"Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection","volume":"373","author":"Ho","year":"1995","journal-title":"Nature"},{"key":"2023062708513781800_B3","volume-title":"Interpolating Cubic Splines","author":"Knott","year":"1999"},{"key":"2023062708513781800_B4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/genetics\/121.1.185","article-title":"Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps","volume":"121","author":"Lander","year":"1989","journal-title":"Genetics"},{"key":"2023062708513781800_B5","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1093\/genetics\/161.4.1751","article-title":"Functional mapping of quantitative trait loci underlying the character process: a theoretical framework","volume":"161","author":"Ma","year":"2002","journal-title":"Genetics"},{"key":"2023062708513781800_B6","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/ng1369","article-title":"Human genes that limit AIDS","volume":"13","author":"O'Brien","year":"2004","journal-title":"Nat. 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