{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:35:58Z","timestamp":1773660958715,"version":"3.50.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Experimentalists have amassed extensive evidence over the past four decades that proteins appear to fold during production by the ribosome. Protein structure prediction methods, however, do not incorporate this property of folding. A thorough study to find the fingerprint of such sequential folding is the first step towards using it in folding algorithms, so assisting structure prediction.<\/jats:p>\n               <jats:p>Results: We explore computationally the existence of evidence for cotranslational folding, based on large sets of experimentally determined structures in the PDB. Our perspective is that cotranslational folding is the norm, but that the effect is masked in most classes. We show that it is most evident in \u03b1\/\u03b2 proteins, confirming recent findings. We also find mild evidence that older proteins may fold cotranslationally. A tool is provided for determining, within a protein, where cotranslation is most evident.<\/jats:p>\n               <jats:p>Contact: gwood@efs.mq.edu.au<\/jats:p>","DOI":"10.1093\/bioinformatics\/btm175","type":"journal-article","created":{"date-parts":[[2007,7,23]],"date-time":"2007-07-23T16:13:46Z","timestamp":1185207226000},"page":"i142-i148","source":"Crossref","is-referenced-by-count":28,"title":["Cotranslational protein folding\u2014fact or fiction?"],"prefix":"10.1093","volume":"23","author":[{"given":"Charlotte M.","family":"Deane","sequence":"first","affiliation":[{"name":"1 Department of Statistics, 1 South Park Road, Oxford University, Oxford OX1 3TG, UK and 2Department of Statistics, Macquarie University, NSW 2109, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingqiang","family":"Dong","sequence":"additional","affiliation":[{"name":"1 Department of Statistics, 1 South Park Road, Oxford University, Oxford OX1 3TG, UK and 2Department of Statistics, Macquarie University, NSW 2109, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabien P.E.","family":"Huard","sequence":"additional","affiliation":[{"name":"1 Department of Statistics, 1 South Park Road, Oxford University, Oxford OX1 3TG, UK and 2Department of Statistics, Macquarie University, NSW 2109, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Braddon K.","family":"Lance","sequence":"additional","affiliation":[{"name":"1 Department of Statistics, 1 South Park Road, Oxford University, Oxford OX1 3TG, UK and 2Department of Statistics, Macquarie University, NSW 2109, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham R.","family":"Wood","sequence":"additional","affiliation":[{"name":"1 Department of Statistics, 1 South Park Road, Oxford University, Oxford OX1 3TG, UK and 2Department of Statistics, Macquarie University, NSW 2109, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,7,1]]},"reference":[{"key":"2023062708512836500_B1","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1002\/pro.5560021121","article-title":"Structural argument for N-terminal initiation of protein folding","volume":"2","author":"Alexandrov","year":"1993","journal-title":"Protein Sci"},{"key":"2023062708512836500_B2","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/4130","article-title":"Metastable states and folding free energy barriers","volume":"5","author":"Baker","year":"1998","journal-title":"Nat. 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