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When combined with additional information, gene expression data in this article, sensitivity and specificity of TFBS search can be improved significantly.<\/jats:p><jats:p>Results: By modifying our previous REFINEMENT approach, we developed dPattern that searches for occurrences of TFBSs in the promotor regions of up\/down regulated or random genes.<\/jats:p><jats:p>Availability: \u00a0http:\/\/platcom.org\/projects\/dpattern<\/jats:p><jats:p>Contact: \u00a0sun.kim@acm.org or sunkim2@indiana.edu<\/jats:p>","DOI":"10.1093\/bioinformatics\/btm288","type":"journal-article","created":{"date-parts":[[2007,6,6]],"date-time":"2007-06-06T01:48:58Z","timestamp":1181094538000},"page":"2619-2621","source":"Crossref","is-referenced-by-count":1,"title":["dPattern: transcription factor binding site (TFBS) discovery in human genome using a discriminative pattern analysis"],"prefix":"10.1093","volume":"23","author":[{"given":"Seung-Hee","family":"Bae","sequence":"first","affiliation":[{"name":"1 Department of Computer Science, 2School of Informatics, 3Center for Genomics and Bioinformatics, Indiana University \u2013 Bloomington, IN 47404 and 4Department of Statistics, Purdue University, West Lafayette, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixu","family":"Tang","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science, 2School of Informatics, 3Center for Genomics and Bioinformatics, Indiana University \u2013 Bloomington, IN 47404 and 4Department of Statistics, Purdue University, West Lafayette, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science, 2School of Informatics, 3Center for Genomics and Bioinformatics, Indiana University \u2013 Bloomington, IN 47404 and 4Department of Statistics, Purdue University, West Lafayette, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Xie","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science, 2School of Informatics, 3Center for Genomics and Bioinformatics, Indiana University \u2013 Bloomington, IN 47404 and 4Department of Statistics, Purdue University, West Lafayette, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science, 2School of Informatics, 3Center for Genomics and Bioinformatics, Indiana University \u2013 Bloomington, IN 47404 and 4Department of Statistics, Purdue University, West Lafayette, IN, USA"},{"name":"1 Department of Computer Science, 2School of Informatics, 3Center for Genomics and Bioinformatics, Indiana University \u2013 Bloomington, IN 47404 and 4Department of Statistics, Purdue University, West Lafayette, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,6,5]]},"reference":[{"key":"2023041208442642300_","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/ng1901","article-title":"Genome-wide analysis of estrogen receptor binding sites","volume":"38","author":"Carroll","year":"2006","journal-title":"Nat. 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