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We developed a web application, the POODLE-S, which predicts the disordered region from amino acid sequences by using physicochemical features and reduced amino acid set of a position-specific scoring matrix.<\/jats:p><jats:p>Availability: POODLE-S is available from http:\/\/mbs.cbrc.jp\/poodle\/poodle-s.html and can be used by both academic and commercial users.<\/jats:p><jats:p>Contact: \u00a0poodle@cbrc.jp<\/jats:p>","DOI":"10.1093\/bioinformatics\/btm330","type":"journal-article","created":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T00:25:06Z","timestamp":1183076706000},"page":"2337-2338","source":"Crossref","is-referenced-by-count":98,"title":["POODLE-S: web application for predicting protein disorder by using physicochemical features and reduced amino acid set of a position-specific scoring matrix"],"prefix":"10.1093","volume":"23","author":[{"given":"Kana","family":"Shimizu","sequence":"first","affiliation":[{"name":"1 Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), 2-42 Aomi, Koto-ku, Tokyo 135-0064 and 2PharmaDesign, Inc., 2-19-8 Hatchobori, Chuo-ku, Tokyo 104-0032, Japan"}]},{"given":"Shuichi","family":"Hirose","sequence":"additional","affiliation":[{"name":"1 Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), 2-42 Aomi, Koto-ku, Tokyo 135-0064 and 2PharmaDesign, Inc., 2-19-8 Hatchobori, Chuo-ku, Tokyo 104-0032, Japan"}]},{"given":"Tamotsu","family":"Noguchi","sequence":"additional","affiliation":[{"name":"1 Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), 2-42 Aomi, Koto-ku, Tokyo 135-0064 and 2PharmaDesign, Inc., 2-19-8 Hatchobori, Chuo-ku, Tokyo 104-0032, Japan"}]}],"member":"286","published-online":{"date-parts":[[2007,6,28]]},"reference":[{"key":"2023041105583010800_","article-title":"LIBSVM : a library for support vector machines","author":"Chang","year":"2001"},{"key":"2023041105583010800_","doi-asserted-by":"crossref","first-page":"6573","DOI":"10.1021\/bi012159+","article-title":"Intrinsic disorder and protein function","volume":"41","author":"Dunker","year":"2002","journal-title":"Biochemistry"},{"key":"2023041105583010800_","first-page":"201","article-title":"Predicting disordered regions from amino acid sequence: common themes despite differing structural characterization","volume":"9","author":"Garner","year":"1998","journal-title":"Genome Inform. 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