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Recent developments include optimization of chemical structure (and substructure) retrieval algorithms, enabling full database searches in less than a second. A text-based search engine allows efficient searching of compounds based on over 65M annotations from over 150 vendors. When searching for chemicals by name, fuzzy text matching capabilities yield productive results even when the correct spelling of a chemical name is unknown, taking advantage of both systematic and common names. Finally, built in reaction models enable searches through virtual chemical space, consisting of hypothetical products readily synthesizable from the building blocks in ChemDB.<\/jats:p><jats:p>Availability: ChemDB and Supplementary Materials are available at http:\/\/cdb.ics.uci.edu.<\/jats:p><jats:p>Contact: \u00a0pfbaldi@ics.uci.edu<\/jats:p><jats:p>Supplementary information: Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btm341","type":"journal-article","created":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T00:25:06Z","timestamp":1183076706000},"page":"2348-2351","source":"Crossref","is-referenced-by-count":121,"title":["ChemDB update\u2014full-text search and virtual chemical space"],"prefix":"10.1093","volume":"23","author":[{"given":"Jonathan H.","family":"Chen","sequence":"first","affiliation":[{"name":"Institute for Genomics and Bioinformatics, School of Information and Computer Sciences, University of California, Irvine, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Linstead","sequence":"additional","affiliation":[{"name":"Institute for Genomics and Bioinformatics, School of Information and Computer Sciences, University of California, Irvine, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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