{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:12:46Z","timestamp":1773274366633,"version":"3.50.1"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Motivation: Reductions in genotyping costs have heightened interest in performing whole genome association scans and in the fine mapping of candidate regions. Improvements in study design and analytic techniques will require the simulation of datasets with realistic patterns of linkage disequilibrium and allele frequencies for typed SNPs.<\/jats:p><jats:p>Methods: We describe a general approach to simulate genotyped datasets for standard case-control or affected child trio data, by resampling from existing phased datasets. The approach allows for considerable flexibility in disease models, potentially involving a large number of interacting loci. The method is most applicable for diseases caused by common variants that have not been under strong selection, a class specifically targeted by the International HapMap project.<\/jats:p><jats:p>Results: Using the three population Phase I\/II HapMap data as a testbed for our approach, we have implemented the approach in HAP-SAMPLE, a web-based simulation tool.<\/jats:p><jats:p>Availability: The web-based tool is available at http:\/\/www.hapsample.org<\/jats:p><jats:p>Contact: \u00a0fwright@bios.unc.edu; fzou@bios.unc.edu;kirk@med.unc.edu<\/jats:p>","DOI":"10.1093\/bioinformatics\/btm386","type":"journal-article","created":{"date-parts":[[2007,9,5]],"date-time":"2007-09-05T00:14:09Z","timestamp":1188951249000},"page":"2581-2588","source":"Crossref","is-referenced-by-count":48,"title":["Simulating association studies: a data-based resampling method for candidate regions or whole genome scans"],"prefix":"10.1093","volume":"23","author":[{"given":"Fred A.","family":"Wright","sequence":"first","affiliation":[{"name":"1 Department of Biostatistics, 2Center for Genome Sciences, 3Center for Environmental Bioinformatics, University of North Carolina, Chapel Hill, NC 27599, 4Renaissance Computing Institute, Europa Drive, 5School of Pharmacy and 6Department of Genetics, UNC Chapel Hill, NC, USA"},{"name":"1 Department of Biostatistics, 2Center for Genome Sciences, 3Center for Environmental Bioinformatics, University of North Carolina, Chapel Hill, NC 27599, 4Renaissance Computing Institute, Europa Drive, 5School of Pharmacy and 6Department of Genetics, UNC Chapel Hill, NC, USA"},{"name":"1 Department of Biostatistics, 2Center for Genome Sciences, 3Center for Environmental Bioinformatics, University of North Carolina, Chapel Hill, NC 27599, 4Renaissance Computing Institute, Europa Drive, 5School of Pharmacy and 6Department of Genetics, UNC Chapel Hill, NC, USA"}]},{"given":"Hanwen","family":"Huang","sequence":"additional","affiliation":[{"name":"1 Department of Biostatistics, 2Center for Genome Sciences, 3Center for Environmental Bioinformatics, University of North Carolina, Chapel Hill, NC 27599, 4Renaissance Computing Institute, Europa Drive, 5School of Pharmacy and 6Department of Genetics, UNC Chapel Hill, NC, USA"}]},{"given":"Xiaojun","family":"Guan","sequence":"additional","affiliation":[{"name":"1 Department of Biostatistics, 2Center for Genome Sciences, 3Center for Environmental Bioinformatics, University of North Carolina, Chapel Hill, NC 27599, 4Renaissance Computing Institute, Europa Drive, 5School of Pharmacy and 6Department of Genetics, UNC Chapel Hill, NC, USA"}]},{"given":"Kevin","family":"Gamiel","sequence":"additional","affiliation":[{"name":"1 Department of Biostatistics, 2Center for Genome Sciences, 3Center for Environmental Bioinformatics, University of North Carolina, Chapel Hill, NC 27599, 4Renaissance Computing Institute, Europa Drive, 5School of Pharmacy and 6Department of Genetics, UNC Chapel Hill, NC, USA"}]},{"given":"Clark","family":"Jeffries","sequence":"additional","affiliation":[{"name":"1 Department of Biostatistics, 2Center for Genome Sciences, 3Center for Environmental Bioinformatics, University of North Carolina, Chapel Hill, NC 27599, 4Renaissance Computing Institute, Europa Drive, 5School of Pharmacy and 6Department of Genetics, UNC Chapel Hill, NC, USA"},{"name":"1 Department of Biostatistics, 2Center for Genome Sciences, 3Center for Environmental Bioinformatics, University of North Carolina, Chapel Hill, NC 27599, 4Renaissance Computing Institute, Europa Drive, 5School of Pharmacy and 6Department of Genetics, UNC Chapel Hill, NC, USA"}]},{"given":"William T.","family":"Barry","sequence":"additional","affiliation":[{"name":"1 Department of Biostatistics, 2Center for Genome Sciences, 3Center for Environmental Bioinformatics, University of North Carolina, Chapel Hill, NC 27599, 4Renaissance Computing Institute, Europa Drive, 5School of Pharmacy and 6Department of Genetics, UNC Chapel Hill, NC, USA"}]},{"given":"Fernando","family":"Pardo-Manuel de Villena","sequence":"additional","affiliation":[{"name":"1 Department of Biostatistics, 2Center for Genome Sciences, 3Center for Environmental Bioinformatics, University of North Carolina, Chapel Hill, NC 27599, 4Renaissance Computing Institute, Europa Drive, 5School of Pharmacy and 6Department of Genetics, UNC Chapel Hill, NC, USA"},{"name":"1 Department of Biostatistics, 2Center for Genome Sciences, 3Center for Environmental Bioinformatics, University of North Carolina, Chapel Hill, NC 27599, 4Renaissance Computing Institute, Europa Drive, 5School of Pharmacy and 6Department of Genetics, UNC Chapel Hill, NC, USA"}]},{"given":"Patrick F.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"1 Department of Biostatistics, 2Center for Genome Sciences, 3Center for Environmental Bioinformatics, University of North Carolina, Chapel Hill, NC 27599, 4Renaissance Computing Institute, Europa Drive, 5School of Pharmacy and 6Department of Genetics, UNC Chapel Hill, NC, USA"},{"name":"1 Department of Biostatistics, 2Center for Genome Sciences, 3Center for Environmental Bioinformatics, University of North Carolina, Chapel Hill, NC 27599, 4Renaissance Computing Institute, Europa Drive, 5School of Pharmacy and 6Department of Genetics, UNC Chapel Hill, NC, USA"}]},{"given":"Kirk C.","family":"Wilhelmsen","sequence":"additional","affiliation":[{"name":"1 Department of Biostatistics, 2Center for Genome Sciences, 3Center for Environmental Bioinformatics, University of North Carolina, Chapel Hill, NC 27599, 4Renaissance Computing Institute, Europa Drive, 5School of Pharmacy and 6Department of Genetics, UNC Chapel Hill, NC, USA"},{"name":"1 Department of Biostatistics, 2Center for Genome Sciences, 3Center for Environmental Bioinformatics, University of North Carolina, Chapel Hill, NC 27599, 4Renaissance Computing Institute, Europa Drive, 5School of Pharmacy and 6Department of Genetics, UNC Chapel Hill, NC, USA"}]},{"given":"Fei","family":"Zou","sequence":"additional","affiliation":[{"name":"1 Department of Biostatistics, 2Center for Genome Sciences, 3Center for Environmental Bioinformatics, University of North Carolina, Chapel Hill, NC 27599, 4Renaissance Computing Institute, Europa Drive, 5School of Pharmacy and 6Department of Genetics, UNC Chapel Hill, NC, USA"},{"name":"1 Department of Biostatistics, 2Center for Genome Sciences, 3Center for Environmental Bioinformatics, University of North Carolina, Chapel Hill, NC 27599, 4Renaissance Computing Institute, Europa Drive, 5School of Pharmacy and 6Department of Genetics, UNC Chapel Hill, NC, USA"},{"name":"1 Department of Biostatistics, 2Center for Genome Sciences, 3Center for Environmental Bioinformatics, University of North Carolina, Chapel Hill, NC 27599, 4Renaissance Computing Institute, Europa Drive, 5School of Pharmacy and 6Department of Genetics, UNC Chapel Hill, NC, USA"}]}],"member":"286","published-online":{"date-parts":[[2007,9,4]]},"reference":[{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nature04226","article-title":"A haplotype map of the human genome","volume":"437","author":"Altshuler","year":"2005","journal-title":"Nature"},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/ng1801","article-title":"Evaluating coverage of genome-wide association studies","volume":"38","author":"Barrett","year":"2006","journal-title":"Nat. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/gepi.20096","article-title":"Haplotype interaction analysis of unlinked regions","volume":"29","author":"Becker","year":"2005","journal-title":"Genet. Epidemiol."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1086\/421051","article-title":"Genetic signatures of strong recent positive selection at the lactase gene","volume":"74","author":"Bersaglieri","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000022963","article-title":"Haplotype evolution and linkage disequilibrium: A simulation study","volume":"51","author":"Calafell","year":"2000","journal-title":"Hum. Hered."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1101\/gr.4107905","article-title":"Ascertainment bias in studies of human genome-wide polymorphism","volume":"15","author":"Clark","year":"2005","journal-title":"Genome Res."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/ng1669","article-title":"Efficiency and power in genetic association studies","volume":"37","author":"de Bakker","year":"2005","journal-title":"Nat. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"12416","DOI":"10.1073\/pnas.95.21.12416","article-title":"Linkage disequilibrium mapping in isolated populations: the example of Finland revisited","volume":"95","author":"De La Chapelle","year":"1998","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1086\/423738","article-title":"Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies","volume":"75","author":"Dudbridge","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"2023041208435172300_","first-page":"499","article-title":"Data simulation software for whole-genome association and other studies in human genetics","volume":"11","author":"Dudek","year":"2006","journal-title":"Proc. Pac. Symp. Biocomput."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1469-1809.1987.tb00875.x","article-title":"Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations","volume":"51","author":"Falk","year":"1987","journal-title":"Ann. Hum. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1126\/science.1105136","article-title":"The ENCODE (ENCyclopedia of DNA elements) Project","volume":"306","author":"Feingold","year":"2004","journal-title":"Science"},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nature02168","article-title":"The International HapMap Project","volume":"426","author":"Gibbs","year":"2003","journal-title":"Nature"},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1136\/jmg.2005.036020","article-title":"An empirical comparison of case-control and trio-based study designs in high-throughput association mapping","volume":"43","author":"Hintsanen","year":"2006","journal-title":"J. Med. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nrg1521","article-title":"Genome-wide association studies for common diseases and complex traits","volume":"6","author":"Hirschhorn","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/genetics\/109.3.611","article-title":"The sampling distribution of linkage disequilibrium under an infinite Allele model without selection","volume":"109","author":"Hudson","year":"1985","journal-title":"Genetics"},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ng917","article-title":"A high-resolution recombination map of the human genome","volume":"31","author":"Kong","year":"2002","journal-title":"Nat. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1093\/bioinformatics\/bth264","article-title":"SIMCOAL 2.0: a program to simulate genomic diversity over large recombining regions in a subdivided population with a complex history","volume":"20","author":"Laval","year":"2004","journal-title":"Bioinformatics"},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/aje\/kwg150","article-title":"Searching for disease-susceptibility loci by testing for Hardy-Weinberg disequilibrium in a gene bank of affected individuals","volume":"158","author":"Lee","year":"2003","journal-title":"Am. J. Epidemiol."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1093\/genetics\/165.4.2213","article-title":"Modeling linkage disequilibrium and identifying recombination hotspots using single-nucleotide polymorphism data","volume":"165","author":"Li","year":"2003","journal-title":"Genetics"},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF03256213","article-title":"A case study of the utility of the HapMap database for pharmacogenomic haplotype analysis in the Taiwanese population","volume":"10","author":"Lin","year":"2006","journal-title":"Mol. Diagn. Ther."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/gepi.20092","article-title":"Multilocus LD measure and tagging SNP selection with generalized mutual information","volume":"29","author":"Liu","year":"2005","journal-title":"Genet. Epidemiol."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/ng1071","article-title":"Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease","volume":"33","author":"Lohmueller","year":"2003","journal-title":"Nat. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/sj.gene.6364064","article-title":"Cost-effective analysis of candidate genes using htSNPs: a staged approach","volume":"5","author":"Lowe","year":"2004","journal-title":"Genes Immun."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1073\/pnas.042680999","article-title":"The first linkage disequilibrium (LD) maps: delineation of hot and cold blocks by diplotype analysis","volume":"99","author":"Maniatis","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/ng1337","article-title":"The effects of human population structure on large genetic association studies","volume":"36","author":"Marchini","year":"2004","journal-title":"Nat. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/ng1537","article-title":"Genome-wide strategies for detecting multiple loci that influence complex diseases","volume":"37","author":"Marchini","year":"2005","journal-title":"Nat. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1086\/500808","article-title":"A comparison of phasing algorithms for trios and unrelated individuals","volume":"78","author":"Marchini","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nmeth718","article-title":"Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays","volume":"1","author":"Matsuzaki","year":"2004","journal-title":"Nat. Methods"},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.1093\/bioinformatics\/bti689","article-title":"HapSim: a simulation tool for generating haplotype data with pre-specified allele frequencies and LD coefficients","volume":"21","author":"Montana","year":"2005","journal-title":"Bioinformatics"},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1126\/science.1117196","article-title":"A fine-scale map of recombination rates and hotspots across the human genome","volume":"310","author":"Myers","year":"2005","journal-title":"Science"},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/hmg\/ddh169","article-title":"Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene","volume":"13","author":"Nejentsev","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1086\/302114","article-title":"Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus","volume":"63","author":"Nielsen","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1534\/genetics.106.058164","article-title":"Simulations provide support for the common disease-common variant hypothesis","volume":"175","author":"Peng","year":"2007","journal-title":"Genetics"},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1371\/journal.pgen.0030047","article-title":"Forward-time simulations of human populations with complex diseases","volume":"3","author":"Peng","year":"2007","journal-title":"PLoS Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/bioinformatics\/19.2.289","article-title":"Simulating haplotype blocks in the human genome","volume":"19","author":"Posada","year":"2003","journal-title":"Bioinformatics"},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","volume":"38","author":"Price","year":"2006","journal-title":"Nat. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1093\/hmg\/11.20.2417","article-title":"The allelic architecture of human disease genes: common disease \u2013 common variant \u2026 or not?","volume":"11","author":"Pritchard","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00439-005-0094-9","article-title":"Evaluating HapMap SNP data transferability in a large-scale genotyping project involving 175 cancer-associated genes","volume":"118","author":"Ribas","year":"2006","journal-title":"Hum. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1126\/science.273.5281.1516","article-title":"The future of genetic studies of complex human diseases","volume":"273","author":"Risch","year":"1996","journal-title":"Science"},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.0006-341X.2004.00207.x","article-title":"Two-stage designs for gene-disease association studies with sample size constraints","volume":"60","author":"Satagopan","year":"2004","journal-title":"Biometrics"},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1101\/gr.3709305","article-title":"Calibrating a coalescent simulation of human genome sequence variation","volume":"15","author":"Schaffner","year":"2005","journal-title":"Genome Res."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1089\/106652703763255642","article-title":"Robustness of inference of haplotype block structure","volume":"10","author":"Schwartz","year":"2003","journal-title":"J. Comput. Biol."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrg1657","article-title":"Mapping by admixture linkage disequilibrium: advances, limitations and guidelines","volume":"6","author":"Smith","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1086\/379378","article-title":"A comparison of Bayesian methods for haplotype reconstruction from population genotype data","volume":"73","author":"Stephens","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"11835","DOI":"10.1073\/pnas.0505262102","article-title":"A map of the human genome in linkage disequilibrium units","volume":"102","author":"Tapper","year":"2005","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/sj.ejhg.5201554","article-title":"Validity of tagging SNPs across populations for association studies","volume":"14","author":"Tenesa","year":"2006","journal-title":"Eur. J. Hum. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1101\/gr.6023607","article-title":"Recent human effective population size estimated from linkage disequilibrium","volume":"17","author":"Tenesa","year":"2007","journal-title":"Genome Res."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1086\/432962","article-title":"Recent developments in genomewide association scans: A workshop summary and review","volume":"77","author":"Thomas","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1086\/507954","article-title":"A genomewide single-nucleotide-polymorphism panel with high ancestry information for African American admixture mapping","volume":"79","author":"Tian","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ng1946","article-title":"Convergent adaptation of human lactase persistence in Africa and Europe","volume":"39","author":"Tishkoff","year":"2007","journal-title":"Nat. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1086\/430472","article-title":"In silico analysis of disease-association mapping strategies using the coalescent process and incorporating ascertainment and selection","volume":"76","author":"Wang","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"2023041208435172300_","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/gepi.20131","article-title":"Tag SNP selection for Finnish individuals based on the CEPH Utah HapMap database","volume":"30","author":"Willer","year":"2006","journal-title":"Genet. Epidemiol."}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/23\/19\/2581\/49857367\/bioinformatics_23_19_2581.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/23\/19\/2581\/49857367\/bioinformatics_23_19_2581.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T01:16:41Z","timestamp":1684027001000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/23\/19\/2581\/186848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,4]]},"references-count":53,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2007,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btm386","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2007,10,1]]},"published":{"date-parts":[[2007,9,4]]}}}