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More specifically, given a set of seed genes which are believed to have a common function, we would like to recruit genes with similar expression profiles as the seed genes in a significant subset of experimental conditions.<\/jats:p><jats:p>Results: We introduce QDB, a novel Bayesian query-driven biclustering framework in which the prior distributions allow introducing knowledge from a set of seed genes (query) to guide the pattern search. In two well-known yeast compendia, we grow highly functionally enriched biclusters from small sets of seed genes using a resolution sweep approach. In addition, relevant conditions are identified and modularity of the biclusters is demonstrated, including the discovery of overlapping modules. Finally, our method deals with missing values naturally, performs well on artificial data from a recent biclustering benchmark study and has a number of conceptual advantages when compared to existing approaches for focused module search.<\/jats:p><jats:p>Availability: Software is available on the Supplementary Material.<\/jats:p><jats:p>Contact: \u00a0thomas.dhollander@esat.kuleuven.be<\/jats:p><jats:p>Supplementary information: Available on http:\/\/homes.esat.kuleuven.be\/~tdhollan\/Supplementary_Information_Dhollander_2007\/index.html<\/jats:p>","DOI":"10.1093\/bioinformatics\/btm387","type":"journal-article","created":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T00:33:40Z","timestamp":1186619620000},"page":"2573-2580","source":"Crossref","is-referenced-by-count":17,"title":["Query-driven module discovery in microarray data"],"prefix":"10.1093","volume":"23","author":[{"given":"Thomas","family":"Dhollander","sequence":"first","affiliation":[{"name":"1 Department of Electrical Engineering ESAT-SCD, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, Leuven-Heverlee 3001 and 2CMPG, Department of Microbial and Molecular Systems, K.U.Leuven, Kasteelpark Arenberg 20, B-3001 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qizheng","family":"Sheng","sequence":"additional","affiliation":[{"name":"1 Department of Electrical Engineering ESAT-SCD, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, Leuven-Heverlee 3001 and 2CMPG, Department of Microbial and Molecular Systems, K.U.Leuven, Kasteelpark Arenberg 20, B-3001 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Lemmens","sequence":"additional","affiliation":[{"name":"1 Department of Electrical Engineering ESAT-SCD, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, Leuven-Heverlee 3001 and 2CMPG, Department of Microbial and Molecular Systems, K.U.Leuven, Kasteelpark Arenberg 20, B-3001 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart","family":"De Moor","sequence":"additional","affiliation":[{"name":"1 Department of Electrical Engineering ESAT-SCD, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, Leuven-Heverlee 3001 and 2CMPG, Department of Microbial and Molecular Systems, K.U.Leuven, Kasteelpark Arenberg 20, B-3001 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Marchal","sequence":"additional","affiliation":[{"name":"1 Department of Electrical Engineering ESAT-SCD, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, Leuven-Heverlee 3001 and 2CMPG, Department of Microbial and Molecular Systems, K.U.Leuven, Kasteelpark Arenberg 20, B-3001 Leuven, Belgium"},{"name":"1 Department of Electrical Engineering ESAT-SCD, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, Leuven-Heverlee 3001 and 2CMPG, Department of Microbial and Molecular Systems, K.U.Leuven, Kasteelpark Arenberg 20, B-3001 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Moreau","sequence":"additional","affiliation":[{"name":"1 Department of Electrical Engineering ESAT-SCD, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, Leuven-Heverlee 3001 and 2CMPG, Department of Microbial and Molecular Systems, K.U.Leuven, Kasteelpark Arenberg 20, B-3001 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,8,8]]},"reference":[{"key":"2023041208445258200_","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1109\/TAC.1974.1100705","article-title":"A new look at the statistical model identification","volume":"19","author":"Akaike","year":"1974","journal-title":"IEEE Transactions on Automatic Control"},{"key":"2023041208445258200_","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. 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