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We present evidence that the DOMON domain along with the DM13 domain comprises a novel electron-transfer system potentially involved in oxidative modification of animal cell-surface proteins. Other novel versions might function as sugar sensors of histidine kinases of bacterial two component systems.<\/jats:p><jats:p>Contact: \u00a0aravind@ncbi.nlm.nih.gov or aravind@mail.nih.gov<\/jats:p><jats:p>Supplementary information: Supplementary data are available at Bioinformatics online and also at ftp:\/\/ftp.ncbi.nih.gov\/pub\/aravind\/domon\/.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btm411","type":"journal-article","created":{"date-parts":[[2007,9,19]],"date-time":"2007-09-19T00:25:25Z","timestamp":1190161525000},"page":"2660-2664","source":"Crossref","is-referenced-by-count":58,"title":["The DOMON domains are involved in heme and sugar recognition"],"prefix":"10.1093","volume":"23","author":[{"given":"Lakshminarayan M.","family":"Iyer","sequence":"first","affiliation":[{"name":"National Center for Biotechnology Information, National Library of Medicine and National Institute of Health, Bethesda, MD 20894, USA"}]},{"given":"Vivek","family":"Anantharaman","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Library of Medicine and National Institute of Health, Bethesda, MD 20894, USA"}]},{"given":"L.","family":"Aravind","sequence":"additional","affiliation":[{"name":"National Center for Biotechnology Information, National Library of Medicine and National Institute of Health, Bethesda, MD 20894, USA"}]}],"member":"286","published-online":{"date-parts":[[2007,9,18]]},"reference":[{"key":"2023041105590590100_","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0968-0004(01)01924-7","article-title":"DOMON: an ancient extracellular domain in dopamine beta-monooxygenase and other proteins","volume":"26","author":"Aravind","year":"2001","journal-title":"Trends Biochem. 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