{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:14:24Z","timestamp":1779106464269,"version":"3.51.4"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":3252,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: The IntAct repository is one of the largest and most widely used databases for the curation and storage of molecular interaction data. These datasets need to be analyzed by computational methods. Software packages in the statistical environment R provide powerful tools for conducting such analyses.<\/jats:p>\n               <jats:p>Results: We introduce Rintact, a Bioconductor package that allows users to transform PSI-MI XML2.5 interaction data files from IntAct into R graph objects. On these, they can use methods from R and Bioconductor for a variety of tasks: determining cohesive subgraphs, computing summary statistics, fitting mathematical models to the data or rendering graphical layouts. Rintact provides a programmatic interface to the IntAct repository and allows the use of the analytic methods provided by R and Bioconductor.<\/jats:p>\n               <jats:p>Availability: \u00a0Rintact is freely available at http:\/\/bioconductor.org<\/jats:p>\n               <jats:p>Contact: \u00a0huber@ebi.ac.uk<\/jats:p>","DOI":"10.1093\/bioinformatics\/btm518","type":"journal-article","created":{"date-parts":[[2007,11,8]],"date-time":"2007-11-08T01:26:33Z","timestamp":1194485193000},"page":"1100-1101","source":"Crossref","is-referenced-by-count":6,"title":["Rintact: enabling computational analysis of molecular interaction data from the IntAct repository"],"prefix":"10.1093","volume":"24","author":[{"given":"Tony","family":"Chiang","sequence":"first","affiliation":[{"name":"1 EBI-EMBL, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK and 2Computational Biology \u2013 FHCRC, 1100 Fairview Avenue North, M2-B876, Seattle, WA 98109, USA"},{"name":"1 EBI-EMBL, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK and 2Computational Biology \u2013 FHCRC, 1100 Fairview Avenue North, M2-B876, Seattle, WA 98109, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nianhua","family":"Li","sequence":"additional","affiliation":[{"name":"1 EBI-EMBL, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK and 2Computational Biology \u2013 FHCRC, 1100 Fairview Avenue North, M2-B876, Seattle, WA 98109, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Orchard","sequence":"additional","affiliation":[{"name":"1 EBI-EMBL, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK and 2Computational Biology \u2013 FHCRC, 1100 Fairview Avenue North, M2-B876, Seattle, WA 98109, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Kerrien","sequence":"additional","affiliation":[{"name":"1 EBI-EMBL, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK and 2Computational Biology \u2013 FHCRC, 1100 Fairview Avenue North, M2-B876, Seattle, WA 98109, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Hermjakob","sequence":"additional","affiliation":[{"name":"1 EBI-EMBL, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK and 2Computational Biology \u2013 FHCRC, 1100 Fairview Avenue North, M2-B876, Seattle, WA 98109, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Gentleman","sequence":"additional","affiliation":[{"name":"1 EBI-EMBL, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK and 2Computational Biology \u2013 FHCRC, 1100 Fairview Avenue North, M2-B876, Seattle, WA 98109, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Huber","sequence":"additional","affiliation":[{"name":"1 EBI-EMBL, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK and 2Computational Biology \u2013 FHCRC, 1100 Fairview Avenue North, M2-B876, Seattle, WA 98109, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,11,7]]},"reference":[{"key":"2023020210005087800_B1","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2006-7-3-r25","article-title":"Ranked prediction of p53 targets using hidden variable dynamic modeling","volume":"7","author":"Barenco","year":"2006","journal-title":"Genome Biol.,"},{"key":"2023020210005087800_B2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1152\/physiolgenomics.2001.7.1.27","article-title":"Two-hybrid analysis of the Saccharomyces cerevisiae 26s proteasome","volume":"7","author":"Cagney","year":"2001","journal-title":"Physiol. 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