{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:59:42Z","timestamp":1758405582072},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: GWAsimulator implements a rapid moving-window algorithm to simulate genotype data for case-control or population samples from genomic SNP chips. For case-control data, the program generates cases and controls according to a user-specified multi-locus disease model, and can simulate specific regions if desired. The program uses phased genotype data as input and has the flexibility of simulating genotypes for different populations and different genomic SNP chips. When the HapMap phased data are used, the simulated data have similar local LD patterns as the HapMap data. As genome-wide association (GWA) studies become increasingly popular and new GWA data analysis methods are being developed, we anticipate that GWAsimulator will be an important tool for evaluating performance of new GWA analysis methods.<\/jats:p>\n               <jats:p>Availability: The C++ source code, executables for Linux, Windows and MacOS, manual, example data sets and analysis program are available at http:\/\/biostat.mc.vanderbilt.edu\/GWAsimulator<\/jats:p>\n               <jats:p>Contact: \u00a0chun.li@vanderbilt.edu<\/jats:p>\n               <jats:p>Supplementary information: Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btm549","type":"journal-article","created":{"date-parts":[[2007,11,16]],"date-time":"2007-11-16T01:43:16Z","timestamp":1195177396000},"page":"140-142","source":"Crossref","is-referenced-by-count":77,"title":["GWAsimulator: a rapid whole-genome simulation program"],"prefix":"10.1093","volume":"24","author":[{"given":"Chun","family":"Li","sequence":"first","affiliation":[{"name":"1 Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 and 2Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyao","family":"Li","sequence":"additional","affiliation":[{"name":"1 Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 and 2Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,11,15]]},"reference":[{"key":"2023020209442985900_B1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"2023020209442985900_B2","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1101\/gr.4107905","article-title":"Ascertainment bias in studies of human genome-wide polymorphism","volume":"15","author":"Clark","year":"2005","journal-title":"Genome Res"},{"key":"2023020209442985900_B3","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev.ge.29.120195.002153","article-title":"Coalescents and genealogical structure under neutrality","volume":"29","author":"Donnelly","year":"1995","journal-title":"Annu. 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