{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:10:42Z","timestamp":1776471042405,"version":"3.51.2"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Mitochondrial genomes encode their own transfer RNAs (tRNAs). These are often degenerate in sequence and structure compared to tRNAs in their bacterial ancestors. This is one of the reasons why current tRNA gene predictor programs perform poorly identifying mitochondrial tRNA genes. As a consequence there is a need for a new program with the specific aim of predicting these tRNAs.<\/jats:p>\n               <jats:p>Results: In this study, we present the software ARWEN that identifies tRNA genes in metazoan mitochondrial nucleotide sequences. ARWEN detects close to 100% of previously annotated genes.<\/jats:p>\n               <jats:p>Availability: An online version, software for download and test results are available at www.acgt.se\/online.html<\/jats:p>\n               <jats:p>Contact: \u00a0bcanback@acgt.se<\/jats:p>\n               <jats:p>Supplementary information: Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btm573","type":"journal-article","created":{"date-parts":[[2007,11,22]],"date-time":"2007-11-22T20:33:56Z","timestamp":1195763636000},"page":"172-175","source":"Crossref","is-referenced-by-count":1254,"title":["ARWEN: a program to detect tRNA genes in metazoan mitochondrial nucleotide sequences"],"prefix":"10.1093","volume":"24","author":[{"given":"Dean","family":"Laslett","sequence":"first","affiliation":[{"name":"1 Murdoch University, Perth, Western Australia, Australia and 2Bj\u00f6rn Canb\u00e4ck Bioinformatik, Vind\u00f6gatan 66, 257 33 Rydeb\u00e4ck, Sweden"}]},{"given":"Bj\u00f6rn","family":"Canb\u00e4ck","sequence":"additional","affiliation":[{"name":"1 Murdoch University, Perth, Western Australia, Australia and 2Bj\u00f6rn Canb\u00e4ck Bioinformatik, Vind\u00f6gatan 66, 257 33 Rydeb\u00e4ck, Sweden"}]}],"member":"286","published-online":{"date-parts":[[2007,11,22]]},"reference":[{"key":"2023020209471468200_B1","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1017\/S1355838200001047","article-title":"Search for characteristic structural features of mammalian mitochondrial tRNAs","volume":"6","author":"Helm","year":"2000","journal-title":"RNA"},{"key":"2023020209471468200_B2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/nar\/gkg077","article-title":"OGRe: a relational database for comparative analysis of mitochondrial genomes","volume":"31","author":"Jameson","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"2023020209471468200_B3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/nar\/gkh152","article-title":"ARAGORN, a program for the detection of transfer RNA and transfer-messenger RNA genes in nucleotide sequences","volume":"32","author":"Laslett","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"2023020209471468200_B4","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1093\/nar\/25.5.955","article-title":"tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence","volume":"25","author":"Lowe","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"2023020209471468200_B5","doi-asserted-by":"crossref","first-page":"D501","DOI":"10.1093\/nar\/gki025","article-title":"NCBI Reference Sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins","volume":"33","author":"Pruitt","year":"2005","journal-title":"Nucleic Acids Res."}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/24\/2\/172\/49044015\/bioinformatics_24_2_172.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/24\/2\/172\/49044015\/bioinformatics_24_2_172.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T04:55:46Z","timestamp":1675313746000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/24\/2\/172\/228155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,22]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,1,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btm573","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2008,1,15]]},"published":{"date-parts":[[2007,11,22]]}}}