{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:25:06Z","timestamp":1785392706496,"version":"3.55.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Continual and accumulated mutations in hemagglutinin (HA) protein of influenza A virus generate novel antigenic strains that cause annual epidemics.<\/jats:p>\n               <jats:p>Results: We propose a model by incorporating scoring and regression methods to predict antigenic variants. Based on collected sequences of influenza A\/H3N2 viruses isolated between 1971 and 2002, our model can be used to accurately predict the antigenic variants in 1999\u20132004 (agreement rate = 91.67%). Twenty amino acid positions identified in our model contribute significantly to antigenic difference and are potential immunodominant positions.<\/jats:p>\n               <jats:p>Contact: hsiung@nhri.org.tw<\/jats:p>\n               <jats:p>Supplementary information: The supplementary information includes 62 amino acid sequences of H3N2 viruses and 277 pair-wise antigenic distances.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btm638","type":"journal-article","created":{"date-parts":[[2008,1,11]],"date-time":"2008-01-11T01:13:48Z","timestamp":1200014028000},"page":"505-512","source":"Crossref","is-referenced-by-count":87,"title":["Bioinformatics models for predicting antigenic variants of influenza A\/H3N2 virus"],"prefix":"10.1093","volume":"24","author":[{"given":"Yu-Chieh","family":"Liao","sequence":"first","affiliation":[{"name":"1 Division of Biostatistics and Bioinformatics and 2Vaccine R&D Center, National Health Research Institutes, Zhunan 350, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Shi","family":"Lee","sequence":"additional","affiliation":[{"name":"1 Division of Biostatistics and Bioinformatics and 2Vaccine R&D Center, National Health Research Institutes, Zhunan 350, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Yu","family":"Ko","sequence":"additional","affiliation":[{"name":"1 Division of Biostatistics and Bioinformatics and 2Vaccine R&D Center, National Health Research Institutes, Zhunan 350, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao A.","family":"Hsiung","sequence":"additional","affiliation":[{"name":"1 Division of Biostatistics and Bioinformatics and 2Vaccine R&D Center, National Health Research Institutes, Zhunan 350, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,1,10]]},"reference":[{"key":"2023020209505660400_B1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jmv.20063","article-title":"Antigenic and molecular analysis of influenza A (H3N2) virus strains isolated from a localised influenza outbreak in South Africa in 2003","volume":"73","author":"Besselaar","year":"2004","journal-title":"J. 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