{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T23:41:56Z","timestamp":1774309316217,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Knowledge of the oligomeric state of a protein is often essential for understanding its function and mechanism. Within a protein crystal, each protein monomer is in contact with many others, forming many small interfaces and a few larger ones that are biologically significant if the protein is a homodimer in solution, but not if the protein is monomeric. Telling such \u2018crystal dimers\u2019 from real ones remains a difficult task.<\/jats:p>\n               <jats:p>Results: It has already been demonstrated that the interfaces of native and non-native protein\u2013protein complexes can be distinguished using a combination of parameters computed with a method on the Voronoi tessellation. We show in this article that the same parameters highlight significant differences between the interfaces of biological and crystal dimers. Using these parameters as descriptors in machine learning methods leads to accurate classification of specific and non-specific protein\u2013protein interfaces.<\/jats:p>\n               <jats:p>Availability: Software is available at http:\/\/fifi.ibbmc.u-psud.fr\/DiMoVo<\/jats:p>\n               <jats:p>Contact: \u00a0anne@rezo.net<\/jats:p>","DOI":"10.1093\/bioinformatics\/btn022","type":"journal-article","created":{"date-parts":[[2008,1,20]],"date-time":"2008-01-20T01:13:55Z","timestamp":1200791635000},"page":"652-658","source":"Crossref","is-referenced-by-count":77,"title":["DiMoVo: a Voronoi tessellation-based method for discriminating crystallographic and biological protein\u2013protein interactions"],"prefix":"10.1093","volume":"24","author":[{"given":"Julie","family":"Bernauer","sequence":"first","affiliation":[{"name":"1 Department of Structural Biology, Fairchild Science Building, Stanford University School of Medicine, Stanford, CA 94305-5126, USA, 2Yeast Structural Genomics, IBBMC UMR 8619, b\u00e2timent 430, Universit\u00e9 Paris-Sud, 91405 Orsay and 3LEBS UPR 9063, CNRS, 91191 Gif-sur-Yvette, France"},{"name":"1 Department of Structural Biology, Fairchild Science Building, Stanford University School of Medicine, Stanford, CA 94305-5126, USA, 2Yeast Structural Genomics, IBBMC UMR 8619, b\u00e2timent 430, Universit\u00e9 Paris-Sud, 91405 Orsay and 3LEBS UPR 9063, CNRS, 91191 Gif-sur-Yvette, France"}]},{"given":"Ranjit Prasad","family":"Bahadur","sequence":"additional","affiliation":[{"name":"1 Department of Structural Biology, Fairchild Science Building, Stanford University School of Medicine, Stanford, CA 94305-5126, USA, 2Yeast Structural Genomics, IBBMC UMR 8619, b\u00e2timent 430, Universit\u00e9 Paris-Sud, 91405 Orsay and 3LEBS UPR 9063, CNRS, 91191 Gif-sur-Yvette, France"}]},{"given":"Francis","family":"Rodier","sequence":"additional","affiliation":[{"name":"1 Department of Structural Biology, Fairchild Science Building, Stanford University School of Medicine, Stanford, CA 94305-5126, USA, 2Yeast Structural Genomics, IBBMC UMR 8619, b\u00e2timent 430, Universit\u00e9 Paris-Sud, 91405 Orsay and 3LEBS UPR 9063, CNRS, 91191 Gif-sur-Yvette, France"}]},{"given":"Jo\u00ebl","family":"Janin","sequence":"additional","affiliation":[{"name":"1 Department of Structural Biology, Fairchild Science Building, Stanford University School of Medicine, Stanford, CA 94305-5126, USA, 2Yeast Structural Genomics, IBBMC UMR 8619, b\u00e2timent 430, Universit\u00e9 Paris-Sud, 91405 Orsay and 3LEBS UPR 9063, CNRS, 91191 Gif-sur-Yvette, France"}]},{"given":"Anne","family":"Poupon","sequence":"additional","affiliation":[{"name":"1 Department of Structural Biology, Fairchild Science Building, Stanford University School of Medicine, Stanford, CA 94305-5126, USA, 2Yeast Structural Genomics, IBBMC UMR 8619, b\u00e2timent 430, Universit\u00e9 Paris-Sud, 91405 Orsay and 3LEBS UPR 9063, CNRS, 91191 Gif-sur-Yvette, France"}]}],"member":"286","published-online":{"date-parts":[[2008,1,19]]},"reference":[{"key":"2023020210105000300_B1","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/prot.10461","article-title":"Dissecting subunit interfaces in homodimeric proteins","volume":"53","author":"Bahadur","year":"2003","journal-title":"Proteins"},{"key":"2023020210105000300_B2","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.jmb.2003.12.073","article-title":"A dissection of specific and non-specific protein-protein interfaces","volume":"336","author":"Bahadur","year":"2004","journal-title":"J. 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