{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:47:55Z","timestamp":1761518875721},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":3098,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: The knowledge base EPO-KB (Empirical Proteomic Ontology Knowledge Base) is based on an OWL ontology that represents current knowledge linking mass-to-charge (m\/z) ratios to proteins on multiple platforms including Matrix Assisted Laser\/Desorption Ionization (MALDI) and Surface Enhanced Laser\/Desorption Ionization (SELDI) \u2013 Time of Flight (TOF). At present, it contains information on m\/z ratio to protein links that were extracted from 120 published research papers. It has a web interface that allows researchers to query and retrieve putative proteins that correspond to a user-specified m\/z ratio. EPO-KB also allows automated entry of additional m\/z ratio to protein links and is expandable to the addition of gene to protein and protein to disease links.<\/jats:p>\n               <jats:p>Availability: http:\/\/www.dbmi.pitt.edu\/EPO-KB<\/jats:p>\n               <jats:p>Contact: \u00a0JLL47@pitt.edu<\/jats:p>","DOI":"10.1093\/bioinformatics\/btn125","type":"journal-article","created":{"date-parts":[[2008,4,10]],"date-time":"2008-04-10T00:25:09Z","timestamp":1207787109000},"page":"1418-1419","source":"Crossref","is-referenced-by-count":15,"title":["EPO-KB: a <i>searchable<\/i> knowledge base of biomarker to protein links"],"prefix":"10.1093","volume":"24","author":[{"given":"Jonathan L.","family":"Lustgarten","sequence":"first","affiliation":[{"name":"1 Department of Biomedical Informatics, University of Pittsburgh, 200 Meyran Ave M-183 Parkvale, Pittsburgh, PA 15260, 2Department of Pathology, University of Pittsburgh and 3University of Pittsburgh Medical Center, Pittsburgh, PA, USA"}]},{"given":"Chad","family":"Kimmel","sequence":"additional","affiliation":[{"name":"1 Department of Biomedical Informatics, University of Pittsburgh, 200 Meyran Ave M-183 Parkvale, Pittsburgh, PA 15260, 2Department of Pathology, University of Pittsburgh and 3University of Pittsburgh Medical Center, Pittsburgh, PA, USA"}]},{"given":"Henrik","family":"Ryberg","sequence":"additional","affiliation":[{"name":"1 Department of Biomedical Informatics, University of Pittsburgh, 200 Meyran Ave M-183 Parkvale, Pittsburgh, PA 15260, 2Department of Pathology, University of Pittsburgh and 3University of Pittsburgh Medical Center, Pittsburgh, PA, USA"}]},{"given":"William","family":"Hogan","sequence":"additional","affiliation":[{"name":"1 Department of Biomedical Informatics, University of Pittsburgh, 200 Meyran Ave M-183 Parkvale, Pittsburgh, PA 15260, 2Department of Pathology, University of Pittsburgh and 3University of Pittsburgh Medical Center, Pittsburgh, PA, USA"},{"name":"1 Department of Biomedical Informatics, University of Pittsburgh, 200 Meyran Ave M-183 Parkvale, Pittsburgh, PA 15260, 2Department of Pathology, University of Pittsburgh and 3University of Pittsburgh Medical Center, Pittsburgh, PA, USA"}]}],"member":"286","published-online":{"date-parts":[[2008,4,9]]},"reference":[{"key":"2023020210061380300_B1","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.1093\/nar\/gkg563","article-title":"ExPASy: The proteomics server for in-depth protein knowledge and analysis","volume":"31","author":"Gasteiger","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"2023020210061380300_B2","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/prot.10336","article-title":"Monte Carlo estimation of the number of possible protein folds: Effects of sampling bias and folds distributions","volume":"51","author":"Hadas Leonov","year":"2003","journal-title":"Prot. 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Prog"},{"key":"2023020210061380300_B8","doi-asserted-by":"crossref","first-page":"D193","DOI":"10.1093\/nar\/gkl929","article-title":"The universal protein resource (UniProt)","volume":"35","author":"The UniProt","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"2023020210061380300_B9","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0169-5002(03)00082-5","article-title":"Discovery of distinct protein profiles specific for lung tumors and pre-malignant lung lesions by SELDI mass spectrometry","volume":"40","author":"Zhukov","year":"2003","journal-title":"Lung Cancer"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/24\/11\/1418\/49048644\/bioinformatics_24_11_1418.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/24\/11\/1418\/49048644\/bioinformatics_24_11_1418.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T11:43:55Z","timestamp":1675338235000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/24\/11\/1418\/190999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,9]]},"references-count":9,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btn125","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2008,6,1]]},"published":{"date-parts":[[2008,4,9]]}}}