{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T20:40:58Z","timestamp":1760820058345},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":3015,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/uk\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: The availability of genome-scale data has enabled an abundance of novel analysis techniques for investigating a variety of systems-level biological relationships. As thousands of such datasets become available, they provide an opportunity to study high-level associations between cellular pathways and processes. This also allows the exploration of shared functional enrichments between diverse biological datasets, and it serves to direct experimenters to areas of low data coverage or with high probability of new discoveries.<\/jats:p>\n               <jats:p>Results: We analyze the functional structure of Saccharomyces cerevisiae datasets from over 950 publications in the context of over 140 biological processes. This includes a coverage analysis of biological processes given current high-throughput data, a data-driven map of associations between processes, and a measure of similar functional activity between genome-scale datasets. This uncovers subtle gene expression similarities in three otherwise disparate microarray datasets due to a shared strain background. We also provide several means of predicting areas of yeast biology likely to benefit from additional high-throughput experimental screens.<\/jats:p>\n               <jats:p>Availability: Predictions are provided in supplementary tables; software and additional data are available from the authors by request.<\/jats:p>\n               <jats:p>Contact: \u00a0ogt@princeton.edu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btn160","type":"journal-article","created":{"date-parts":[[2008,6,27]],"date-time":"2008-06-27T07:43:13Z","timestamp":1214552593000},"page":"i330-i338","source":"Crossref","is-referenced-by-count":14,"title":["Assessing the functional structure of genomic data"],"prefix":"10.1093","volume":"24","author":[{"given":"C.","family":"Huttenhower","sequence":"first","affiliation":[{"name":"1 Department of Computer Science, Princeton University, 35 Olden Street, Princeton, NJ 08540 and 2Lewis Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University, Princeton, NJ 08544, USA"},{"name":"1 Department of Computer Science, Princeton University, 35 Olden Street, Princeton, NJ 08540 and 2Lewis Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University, Princeton, NJ 08544, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.G.","family":"Troyanskaya","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science, Princeton University, 35 Olden Street, Princeton, NJ 08540 and 2Lewis Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University, Princeton, NJ 08544, USA"},{"name":"1 Department of Computer Science, Princeton University, 35 Olden Street, Princeton, NJ 08540 and 2Lewis Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University, Princeton, NJ 08544, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,7,1]]},"reference":[{"key":"2023020210410230300_B1","doi-asserted-by":"crossref","first-page":"D418","DOI":"10.1093\/nar\/gki051","article-title":"The Biomolecular Interaction Network Database and related tools 2005 update","volume":"33","author":"Alfarano","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"2023020210410230300_B2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. 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