{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:40:08Z","timestamp":1779169208287,"version":"3.51.4"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8,1]]},"abstract":"Abstract<\/jats:title>\n Jain et al. introduced the Local Pooled Error (LPE) statistical test designed for use with small sample size microarray gene-expression data. Based on an asymptotic proof, the test multiplicatively adjusts the standard error for a test of differences between two classes of observations by \u03c0\/2 due to the use of medians rather than means as measures of central tendency. The adjustment is upwardly biased at small sample sizes, however, producing fewer than expected small P-values with a consequent loss of statistical power. We present an empirical correction to the adjustment factor which removes the bias and produces theoretically expected P-values when distributional assumptions are met. Our adjusted LPE measure should prove useful to ongoing methodological studies designed to improve the LPE's; performance for microarray and proteomics applications and for future work for other high-throughput biotechnologies.<\/jats:p>\n Availability: The software is implemented in the R language and can be downloaded from the Bioconductor project website (http:\/\/www.bioconductor.org).<\/jats:p>\n Contact: \u00a0robert.nadon@mcgill.ca<\/jats:p>","DOI":"10.1093\/bioinformatics\/btn211","type":"journal-article","created":{"date-parts":[[2008,5,4]],"date-time":"2008-05-04T04:47:30Z","timestamp":1209876450000},"page":"1735-1736","source":"Crossref","is-referenced-by-count":5,"title":["A correction for estimating error when using the Local Pooled Error Statistical Test"],"prefix":"10.1093","volume":"24","author":[{"given":"Carl","family":"Murie","sequence":"first","affiliation":[{"name":"1 McGill University and Genome Quebec Innovation Centre, 740 avenue du Docteur Penfield, Montreal, Quebec, Canada, H3A 1A4 and 2McGill University, Department of Human Genetics, Montreal, 1205 avenue du Docteur Penfield N5\/13, Quebec, Canada, H3A 1A4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Nadon","sequence":"additional","affiliation":[{"name":"1 McGill University and Genome Quebec Innovation Centre, 740 avenue du Docteur Penfield, Montreal, Quebec, Canada, H3A 1A4 and 2McGill University, Department of Human Genetics, Montreal, 1205 avenue du Docteur Penfield N5\/13, Quebec, Canada, H3A 1A4"},{"name":"1 McGill University and Genome Quebec Innovation Centre, 740 avenue du Docteur Penfield, Montreal, Quebec, Canada, H3A 1A4 and 2McGill University, Department of Human Genetics, Montreal, 1205 avenue du Docteur Penfield N5\/13, Quebec, Canada, H3A 1A4"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,5,1]]},"reference":[{"key":"2023020210482657600_B1","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1002\/pmic.200300840","article-title":"In vitro and in silico processes to identify differentially expressed proteins","volume":"4","author":"Allet","year":"2004","journal-title":"Proteomics"},{"key":"2023020210482657600_B2","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1093\/bioinformatics\/bth192","article-title":"Bayesian hierarchical error model for analysis of gene expression data","volume":"20","author":"Cho","year":"2004","journal-title":"Bioinformatics"},{"key":"2023020210482657600_B3","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1002\/pmic.200601034","article-title":"Statistical identification of differentially labeled peptides from liquid chromatography tandem mass spectrometry","volume":"7","author":"Cho","year":"2007","journal-title":"Proteomics"},{"key":"2023020210482657600_B4","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1093\/bioinformatics\/btg264","article-title":"Local pooled error test for identifying differentially expressed genes with a small number of replicated microarrays","volume":"19","author":"Jain","year":"2003","journal-title":"Bioinformatics"},{"key":"2023020210482657600_B5","volume-title":"Introduction to the theory of statistics","author":"Mood","year":"1974"},{"key":"2023020210482657600_B6","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1093\/nar\/gkm130","article-title":"Error-pooling-based statistical methods for identifying novel temporal replication profiles of human chromosomes observed by DNA tiling arrays","volume":"35","author":"Park","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"2023020210482657600_B7","volume-title":"Kendall's Advanced Theory of Statistics, Vol. 1, Distribution Theory","author":"Stuart","year":"1994"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/24\/15\/1735\/49048152\/bioinformatics_24_15_1735.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/24\/15\/1735\/49048152\/bioinformatics_24_15_1735.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T10:49:12Z","timestamp":1675334952000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/24\/15\/1735\/264344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,1]]},"references-count":7,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2008,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btn211","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2008,8,1]]},"published":{"date-parts":[[2008,5,1]]}}}