{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T16:40:02Z","timestamp":1738255202084,"version":"3.35.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Summary: Existing linkage-analysis methods address binary or quantitative traits. However, many complex diseases and human conditions, particularly behavioral disorders, are rated on ordinal scales. Herein, we introduce, LOT, a tool that performs linkage analysis of ordinal traits for pedigree data. It implements a latent-variable proportional-odds logistic model that relates inheritance patterns to the distribution of the ordinal trait. The likelihood-ratio test is used for testing evidence of linkage.<\/jats:p><jats:p>Availability: The LOT program is available for download at http:\/\/c2s2.yale.edu\/software\/LOT\/<\/jats:p><jats:p>Contact: \u00a0heping.zhang@yale.edu<\/jats:p>","DOI":"10.1093\/bioinformatics\/btn258","type":"journal-article","created":{"date-parts":[[2008,6,6]],"date-time":"2008-06-06T00:45:31Z","timestamp":1212713131000},"page":"1737-1739","source":"Crossref","is-referenced-by-count":3,"title":["LOT: a tool for linkage analysis of ordinal traits for pedigree data"],"prefix":"10.1093","volume":"24","author":[{"given":"Meizhuo","family":"Zhang","sequence":"first","affiliation":[{"name":"1 Yale University School of Medicine, New Haven, CT 06520-8034 and 2University of Alabama at Birmingham, Birmingham, Alabama 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Feng","sequence":"additional","affiliation":[{"name":"1 Yale University School of Medicine, New Haven, CT 06520-8034 and 2University of Alabama at Birmingham, Birmingham, Alabama 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[{"name":"1 Yale University School of Medicine, New Haven, CT 06520-8034 and 2University of Alabama at Birmingham, Birmingham, Alabama 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buqu","family":"Hu","sequence":"additional","affiliation":[{"name":"1 Yale University School of Medicine, New Haven, CT 06520-8034 and 2University of Alabama at Birmingham, Birmingham, Alabama 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heping","family":"Zhang","sequence":"additional","affiliation":[{"name":"1 Yale University School of Medicine, New Haven, CT 06520-8034 and 2University of Alabama at Birmingham, Birmingham, Alabama 35294, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,6,5]]},"reference":[{"key":"2023020210482824800_B1","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1086\/343822","article-title":"Genomewide linkage analysis of body mass index across 28 years of the Framingham Heart Study","volume":"70","author":"Atwood","year":"2002","journal-title":"Am. 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