{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:39:27Z","timestamp":1758476367429},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: In principle, an organism's ability to survive in a specific environment, is an observable result of the organism's regulatory and metabolic capabilities. Nonetheless, current knowledge about the global relation of the metabolisms and the niches of organisms is still limited.<\/jats:p>\n               <jats:p>Results: In order to further investigate this relation, we grouped species showing similar metabolic capabilities and systematically mapped their habitats onto these groups. For this purpose, we predicted the metabolic capabilities for 214 sequenced genomes. Based on these predictions, we grouped the genomes by hierarchical clustering. Finally, we mapped different environmental conditions and diseases related to the genomes onto the resulting clusters. This mapping uncovered several conditions and diseases that were unexpectedly enriched in clusters of metabolically similar species. As an example, Encephalitozoon cuniculi\u2014a microsporidian causing a multisystemic disease accompanied by CNS problems in rabbits\u2014 occurred in the same metabolism-based cluster as bacteria causing similar symptoms in humans.<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <jats:p>Contact: \u00a0g.kastenmueller@helmholtz-muenchen.de<\/jats:p>","DOI":"10.1093\/bioinformatics\/btn302","type":"journal-article","created":{"date-parts":[[2008,8,9]],"date-time":"2008-08-09T13:08:02Z","timestamp":1218287282000},"page":"i56-i62","source":"Crossref","is-referenced-by-count":7,"title":["An environmental perspective on large-scale genome clustering based on metabolic capabilities"],"prefix":"10.1093","volume":"24","author":[{"given":"Gabi","family":"Kastenm\u00fcller","sequence":"first","affiliation":[{"name":"1 Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen\u2014German Research Center for Environmental Health, Ingolst\u00e4dter Landstra\u00dfe 1, D-85764 Neuherberg, 2Computer-Chemie-Centrum, University of Erlangen-N\u00fcrnberg, N\u00e4gelsbachstra\u00dfe 25, D-91052 Erlangen, 3Molecular Networks GmbH, Henkestra\u00dfe 91, D-91052 Erlangen and 4Chair for Genome-Oriented Bioinformatics, Technische Universit\u00e4t M\u00fcnchen, Life and Food Science Center Weihenstephan, Am Forum 1, D-85354 Freising-Weihenstephan, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johann","family":"Gasteiger","sequence":"additional","affiliation":[{"name":"1 Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen\u2014German Research Center for Environmental Health, Ingolst\u00e4dter Landstra\u00dfe 1, D-85764 Neuherberg, 2Computer-Chemie-Centrum, University of Erlangen-N\u00fcrnberg, N\u00e4gelsbachstra\u00dfe 25, D-91052 Erlangen, 3Molecular Networks GmbH, Henkestra\u00dfe 91, D-91052 Erlangen and 4Chair for Genome-Oriented Bioinformatics, Technische Universit\u00e4t M\u00fcnchen, Life and Food Science Center Weihenstephan, Am Forum 1, D-85354 Freising-Weihenstephan, Germany"},{"name":"1 Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen\u2014German Research Center for Environmental Health, Ingolst\u00e4dter Landstra\u00dfe 1, D-85764 Neuherberg, 2Computer-Chemie-Centrum, University of Erlangen-N\u00fcrnberg, N\u00e4gelsbachstra\u00dfe 25, D-91052 Erlangen, 3Molecular Networks GmbH, Henkestra\u00dfe 91, D-91052 Erlangen and 4Chair for Genome-Oriented Bioinformatics, Technische Universit\u00e4t M\u00fcnchen, Life and Food Science Center Weihenstephan, Am Forum 1, D-85354 Freising-Weihenstephan, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Werner","family":"Mewes","sequence":"additional","affiliation":[{"name":"1 Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen\u2014German Research Center for Environmental Health, Ingolst\u00e4dter Landstra\u00dfe 1, D-85764 Neuherberg, 2Computer-Chemie-Centrum, University of Erlangen-N\u00fcrnberg, N\u00e4gelsbachstra\u00dfe 25, D-91052 Erlangen, 3Molecular Networks GmbH, Henkestra\u00dfe 91, D-91052 Erlangen and 4Chair for Genome-Oriented Bioinformatics, Technische Universit\u00e4t M\u00fcnchen, Life and Food Science Center Weihenstephan, Am Forum 1, D-85354 Freising-Weihenstephan, Germany"},{"name":"1 Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen\u2014German Research Center for Environmental Health, Ingolst\u00e4dter Landstra\u00dfe 1, D-85764 Neuherberg, 2Computer-Chemie-Centrum, University of Erlangen-N\u00fcrnberg, N\u00e4gelsbachstra\u00dfe 25, D-91052 Erlangen, 3Molecular Networks GmbH, Henkestra\u00dfe 91, D-91052 Erlangen and 4Chair for Genome-Oriented Bioinformatics, Technische Universit\u00e4t M\u00fcnchen, Life and Food Science Center Weihenstephan, Am Forum 1, D-85354 Freising-Weihenstephan, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,8,9]]},"reference":[{"key":"2023020210501918800_B1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jmb.2004.04.059","article-title":"Analysis of phenetic trees based on metabolic capabilites across the three domains of life","volume":"340","author":"Aguilar","year":"2004","journal-title":"J. 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