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It reconstructs the substitution history of the alignment by maximum likelihood-based phylogenetic methods, and then analyzes the joint distribution of substitution events using Bayesian graphical models to identify significant associations among sites.<\/jats:p>\n               <jats:p>Availability: Spidermonkey is publicly available both as a web application at http:\/\/www.data-monkey.org and as a stand-alone component of the phylogenetic software package HyPhy, which is freely distributed on the web (http:\/\/www.hyphy.org) as precompiled binaries and open source.<\/jats:p>\n               <jats:p>Contact: \u00a0afpoon@ucsd.edu<\/jats:p>","DOI":"10.1093\/bioinformatics\/btn313","type":"journal-article","created":{"date-parts":[[2008,6,19]],"date-time":"2008-06-19T00:14:16Z","timestamp":1213834456000},"page":"1949-1950","source":"Crossref","is-referenced-by-count":72,"title":["Spidermonkey: rapid detection of co-evolving sites using Bayesian graphical models"],"prefix":"10.1093","volume":"24","author":[{"given":"Art F. Y.","family":"Poon","sequence":"first","affiliation":[{"name":"1 Division of Comparative Pathology and Medicine, Department of Pathology, University of California, San Diego, CA 92103, USA and 2Epidemiology Research Unit, Scottish Agricultural College, Inverness, Scotland, IV2 4JZ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fraser I.","family":"Lewis","sequence":"additional","affiliation":[{"name":"1 Division of Comparative Pathology and Medicine, Department of Pathology, University of California, San Diego, CA 92103, USA and 2Epidemiology Research Unit, Scottish Agricultural College, Inverness, Scotland, IV2 4JZ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon D. 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