{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T22:52:02Z","timestamp":1768431122551,"version":"3.49.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Gaussian processes (GPs) are flexible statistical models commonly used for predicting output from complex computer codes. As such, GPs are well suited for the analysis of computer models of biological systems, which have been traditionally difficult to analyze due to their high-dimensional, non-linear and resource-intensive nature. We describe an R package, mlegp, that fits GPs to computer model outputs and performs sensitivity analysis to identify and characterize the effects of important model inputs.<\/jats:p>\n               <jats:p>Availability: \u00a0http:\/\/www.biomath.org\/mlegp<\/jats:p>\n               <jats:p>Contact: \u00a0kdorman@iastate.edu<\/jats:p>\n               <jats:p>Supplementary information: See http:\/\/www.biomath.org\/mlegp for a user manual and examples.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btn329","type":"journal-article","created":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T00:25:07Z","timestamp":1216340707000},"page":"1966-1967","source":"Crossref","is-referenced-by-count":32,"title":["<i>mlegp<\/i>: statistical analysis for computer models of biological systems using R"],"prefix":"10.1093","volume":"24","author":[{"given":"Garrett M.","family":"Dancik","sequence":"first","affiliation":[{"name":"1 Program in Bioinformatics & Computational Biology, 2Department of Statistics and 3Department of Genetics, Development & Cell Biology, Iowa State University, Ames, IA 50010, USA"},{"name":"1 Program in Bioinformatics & Computational Biology, 2Department of Statistics and 3Department of Genetics, Development & Cell Biology, Iowa State University, Ames, IA 50010, USA"}]},{"given":"Karin S.","family":"Dorman","sequence":"additional","affiliation":[{"name":"1 Program in Bioinformatics & Computational Biology, 2Department of Statistics and 3Department of Genetics, Development & Cell Biology, Iowa State University, Ames, IA 50010, USA"},{"name":"1 Program in Bioinformatics & Computational Biology, 2Department of Statistics and 3Department of Genetics, Development & Cell Biology, Iowa State University, Ames, IA 50010, USA"},{"name":"1 Program in Bioinformatics & Computational Biology, 2Department of Statistics and 3Department of Genetics, Development & Cell Biology, Iowa State University, Ames, IA 50010, USA"}]}],"member":"286","published-online":{"date-parts":[[2008,6,17]]},"reference":[{"key":"2023020211101119200_B1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1198\/004017007000000092","article-title":"A framework for validation of computer models.","volume":"49","author":"Bayarri","year":"2007","journal-title":"Technometrics"},{"key":"2023020211101119200_B2","first-page":"1853","article-title":"An agent-based model for Leishmania infection.","author":"Dancik","year":"2006","journal-title":"Interj. 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