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In this article, we investigate whether ensemble tree classifiers can ameliorate these difficulties, using data from two recent studies of radical prostatectomy in prostate cancer.<\/jats:p>\n               <jats:p>Results: Using time to progression following prostatectomy as the relevant clinical endpoint, we found that ensemble tree classifiers robustly and reproducibly identified three subgroups of patients in the two clinical datasets: non-progressors, early progressors and late progressors. Moreover, the consensus classifications were independent predictors of time to progression compared to known clinical prognostic factors.<\/jats:p>\n               <jats:p>Contact: \u00a0dmercola@uci.edu<\/jats:p>","DOI":"10.1093\/bioinformatics\/btn354","type":"journal-article","created":{"date-parts":[[2008,7,16]],"date-time":"2008-07-16T03:24:35Z","timestamp":1216178675000},"page":"54-60","source":"Crossref","is-referenced-by-count":20,"title":["The wisdom of the commons: ensemble tree classifiers for prostate cancer prognosis"],"prefix":"10.1093","volume":"25","author":[{"given":"James A.","family":"Koziol","sequence":"first","affiliation":[{"name":"1 The Scripps Research Institute, La Jolla, 2Translational Cancer Biology, Department of Pathology and Laboratory Medicine, University of California, Irvine, 3The Sidney Kimmel Cancer Center, San Diego, CA and 4Department of Surgery, University of Florida, Shands Health Science Center, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne C.","family":"Feng","sequence":"additional","affiliation":[{"name":"1 The Scripps Research Institute, La Jolla, 2Translational Cancer Biology, Department of Pathology and Laboratory Medicine, University of California, Irvine, 3The Sidney Kimmel Cancer Center, San Diego, CA and 4Department of Surgery, University of Florida, Shands Health Science Center, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Jia","sequence":"additional","affiliation":[{"name":"1 The Scripps Research Institute, La Jolla, 2Translational Cancer Biology, Department of Pathology and Laboratory Medicine, University of California, Irvine, 3The Sidney Kimmel Cancer Center, San Diego, CA and 4Department of Surgery, University of Florida, Shands Health Science Center, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yipeng","family":"Wang","sequence":"additional","affiliation":[{"name":"1 The Scripps Research Institute, La Jolla, 2Translational Cancer Biology, Department of Pathology and Laboratory Medicine, University of California, Irvine, 3The Sidney Kimmel Cancer Center, San Diego, CA and 4Department of Surgery, University of Florida, Shands Health Science Center, Jacksonville, FL, USA"},{"name":"1 The Scripps Research Institute, La Jolla, 2Translational Cancer Biology, Department of Pathology and Laboratory Medicine, University of California, Irvine, 3The Sidney Kimmel Cancer Center, San Diego, CA and 4Department of Surgery, University of Florida, Shands Health Science Center, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seven","family":"Goodison","sequence":"additional","affiliation":[{"name":"1 The Scripps Research Institute, La Jolla, 2Translational Cancer Biology, Department of Pathology and Laboratory Medicine, University of California, Irvine, 3The Sidney Kimmel Cancer Center, San Diego, CA and 4Department of Surgery, University of Florida, Shands Health Science Center, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"McClelland","sequence":"additional","affiliation":[{"name":"1 The Scripps Research Institute, La Jolla, 2Translational Cancer Biology, Department of Pathology and Laboratory Medicine, University of California, Irvine, 3The Sidney Kimmel Cancer Center, San Diego, CA and 4Department of Surgery, University of Florida, Shands Health Science Center, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Mercola","sequence":"additional","affiliation":[{"name":"1 The Scripps Research Institute, La Jolla, 2Translational Cancer Biology, Department of Pathology and Laboratory Medicine, University of California, Irvine, 3The Sidney Kimmel Cancer Center, San Diego, CA and 4Department of Surgery, University of Florida, Shands Health Science Center, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,7,15]]},"reference":[{"key":"2023013110083791600_B1","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/pmic.200500192","article-title":"A robust meta-classification strategy for cancer detection from MS data","volume":"6","author":"Bhanot","year":"2006","journal-title":"Proteomics"},{"key":"2023013110083791600_B2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF00058655","article-title":"Bagging predictors","volume":"24","author":"Breiman","year":"1996","journal-title":"Mach. 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